Liver transplantation outcomes in patients with primary tricuspid regurgitation with coaptation defects: A retrospective analysis in a high-volume transplant center.

Abstract

Background: Cardiovascular diseases are the leading cause of mortality after liver transplantation(LT). Although the impact of secondary tricuspid regurgitation (TR) with severe pulmonary hypertension(PH) is well investigated, the impact of primary TR with tricuspid valve incompetence(TVI) on LT outcomes remains unclear. We aimed to investigate the prevalence and impact of primary TR with TVI on LT outcomes in a large-volume LT center.

Methods: We retrospectively examined 5,512 consecutive LT recipients who underwent routine pretransplant echocardiography between 2008 and 2020. Patients were categorized based on the presence of anatomical TVI, specifically defined by incomplete coaptation, coaptation failure, prolapse, and flail leaflets of tricuspid valve(TV). Propensity score (PS)-based inverse probability weighting(IPW) was used to balance clinical and cardiovascular risk variables. The outcomes were one-year cumulative all-cause mortality and 30-day major adverse cardiovascular events(MACE).

Results: Anatomical TVI was identified in 14 patients(0.3%). Although rare, these patients exhibited significantly lower post-LT one-year survival rates (64.3% vs. 91.5%, P < 0.001) and higher 30-day MACE rates(42.9% vs. 16.9%, P = 0.026) than patients without TVI. They also had worse survival irrespective of echocardiographic evidence of PH (P < 0.001) and exhibited higher one-year mortality(IPW-adjusted hazard ratio [HR]: 4.09, P = 0.002) and increased 30-day MACE rates(IPW-adjusted odds ratio [OR]: 1.24, P = 0.048).

Conclusions: Primary TR with anatomical TVI was associated with significantly reduced one-year survival and increased post-LT MACE rates. These patients should be prioritized similarly to those with secondary TR with severe PH, with appropriate pretransplant evaluations and treatments to improve survival outcomes.