Factors affecting the postoperative survival rate of obese Asian patients with endometrial cancer.

IF 0.9 4区医学 Q4 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-03-26 DOI:10.1080/01443615.2025.2480856

Huiqiao Gao, Qi Lu, Jianxin Zhang

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Abstract

Background: The objective of this study was to explore the factors that influence overall survival in obese patients with endometrial cancer (EC).

Methods: The retrospective study included patients with EC who were treated between 2000 and April 2013. Subjects were divided into the following groups based on body mass index (BMI): non-obese (<24.0 kg/m²), overweight (24.0-28.0 kg/m²) and obese (>28.0 kg/m²). Survival data were estimated using Kaplan-Meier's curves and compared using log-rank statistics.

Results: A total of 280 cases were enrolled, including 22.5% in non-obese group, 42.9% in overweight group and 34.6% in obese group. Among different BMI groups, obese EC patients with diabetes have a lower survival rate (p = .041), and obese EC patients with menopause have a lower survival rate (p = .021). The survival rate of overweight EC patients was significantly reduced if vascular thrombus and lymph node metastasis were found during operation (p < .001).

Conclusions: Our data suggest that the association of obese EC patients with menstrual status, diabetes and intraoperative vasculature embolus and lymph node metastasis significantly affects postoperative survival. In all subjects, the relevant factors were independent prognostic factors in patients with obese.

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影响亚洲肥胖子宫内膜癌患者术后生存率的因素。

背景：本研究的目的是探讨影响肥胖子宫内膜癌（EC）患者总体生存的因素。方法：回顾性研究纳入2000年至2013年4月期间接受治疗的EC患者。根据体重指数（BMI）将受试者分为非肥胖组(2)、超重组（24.0 ~ 28.0 kg/m2）和肥胖组（bb0 ~ 28.0 kg/m2）。生存数据用Kaplan-Meier曲线估计，用log-rank统计进行比较。结果：共入组280例，其中非肥胖组22.5%，超重组42.9%，肥胖组34.6%。在不同BMI组中，肥胖EC合并糖尿病患者生存率较低（p = 0.041），肥胖EC合并绝经患者生存率较低（p = 0.021）。结论：我们的数据提示，肥胖EC患者与月经状况、糖尿病、术中血管栓子和淋巴结转移的相关性显著影响术后生存率。在所有受试者中，相关因素均为肥胖患者的独立预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology 医学-妇产科学

CiteScore

2.40

自引率

7.70%

发文量

398

审稿时长

6 months

期刊介绍： Journal of Obstetrics and Gynaecology represents an established forum for the entire field of obstetrics and gynaecology, publishing a broad range of original, peer-reviewed papers, from scientific and clinical research to reviews relevant to practice. It also includes occasional supplements on clinical symposia. The journal is read widely by trainees in our specialty and we acknowledge a major role in education in Obstetrics and Gynaecology. Past and present editors have recognized the difficulties that junior doctors encounter in achieving their first publications and spend time advising authors during their initial attempts at submission. The journal continues to attract a world-wide readership thanks to the emphasis on practical applicability and its excellent record of drawing on an international base of authors.