Different Patterns of the Relationship Between Gynecological Malignancy and Obesity Index: A Nationwide Retrospective Cohort Study in Korea.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Seo Young Kang, Ye-Jee Kim, Sehee Kim, Hye Soon Park
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引用次数: 0

Abstract

Background: In Korea, the patterns of prevalence of gynecological cancers have shifted due to rising obesity-related cancer cases. We evaluated the associations of body mass index (BMI) and waist circumference (WC) with the risk of gynecological malignancy in Korean women.

Methods: Using National Health Insurance Service cohort data, we analyzed 365,581 participants among the 1,999,980 women aged ≥ 19 years who underwent health check-ups at the baseline year 2009-2010, excluding those who died, those with prior cancer diagnoses, underwent hysterectomy and/or salpingo-oophorectomy before the index date (January 1st, 2011), or missing/outliers BMI and WC values. Follow-up extended to December 31st, 2021, evaluating the incidences of endometrial, ovarian, and cervical cancer. The hazard ratios (HRs) and 95% confidence intervals (CIs) for each gynecological malignancy according to BMI and WC were calculated using Cox proportional hazard regression.

Results: Among the 365,581 participants, 898, 1,268, and 873 cases of endometrial, ovarian, and cervical cancer occurred, respectively. HRs (95% CIs) for endometrial cancer were 1.37 (1.15-1.63), 1.63 (1.38-1.94), and 3.64 (2.81-4.70) for BMIs of 23.0-24.9, 25.0-29.9, and ≥ 30 kg/m² compared to BMI of 18.5-22.9 kg/m² (P for trend < 0.001). HRs (95% CIs) for ovarian cancer were 1.16 (1.00-1.33), 1.19 (1.03-1.37), and 1.49 (1.12-1.98) for BMIs of 23.0-24.9, 25.0-29.9, and ≥ 30 kg/m² compared to BMI of 18.5-22.9 kg/m² (P for trend = 0.002). No significant association was found between BMI and the risk for cervical cancer (P for trend = 0.266). HRs (95% CIs) for endometrial cancer were 1.35 (1.09-1.66), 1.41 (1.14-1.74), and 1.90 (1.55-2.34) for the 2nd, 3rd, and 4th quartiles of WCs compared to the 1st quartile (P for trend <0.001). Ovarian cancer tended to increase and cervical cancer tended to decrease as WC increased (P for trend = 0.035 for ovarian cancer, P for trend = 0.034 for cervical cancer).

Conclusion: In Korean women, the risks of endometrial and ovarian cancers increased significantly from the pre-obese level as BMI and WC increased, while cervical cancer risk tended to increase as WC decreased. Management of obesity should be reinforced for the prevention of obesity-related gynecological cancers, considering the increasing incidence of these cancers among Korean women.

妇科恶性肿瘤与肥胖指数之间关系的不同模式:韩国全国回顾性队列研究。
背景:在韩国,由于肥胖相关癌症病例的增加,妇科癌症的流行模式发生了变化。我们评估了韩国女性身体质量指数(BMI)和腰围(WC)与妇科恶性肿瘤风险的关系。方法:使用国民健康保险服务队列数据,我们分析了在2009-2010年基线年进行健康检查的1,999,980名年龄≥19岁的女性中的365,581名参与者,排除了死亡,既往癌症诊断,在指数日期(2011年1月1日)之前进行子宫切除术和/或输卵管卵巢切除术,或缺失/异常值的BMI和WC值。随访延长至2021年12月31日,评估子宫内膜癌、卵巢癌和宫颈癌的发病率。采用Cox比例风险回归计算各妇科恶性肿瘤BMI和WC的风险比(hr)和95%可信区间(ci)。结果:在365,581名参与者中,分别发生了898例、1268例和873例子宫内膜癌、卵巢癌和宫颈癌。与BMI为18.5-22.9 kg/m²相比,BMI为23.0-24.9、25.0-29.9和≥30 kg/m²的子宫内膜癌的HRs (95% ci)分别为1.37(1.15-1.63)、1.63(1.38-1.94)和3.64(2.81-4.70)。与BMI为18.5-22.9 kg/m²相比,BMI为23.0-24.9、25.0-29.9和≥30 kg/m²的卵巢癌患者的hr (95% ci)分别为1.16(1.00-1.33)、1.19(1.03-1.37)和1.49(1.12-1.98)(趋势P = 0.002)。BMI与子宫颈癌风险之间无显著关联(趋势P = 0.266)。子宫内膜癌第2、3、4四分位数与第1四分位数相比的hr (95% ci)分别为1.35(1.09-1.66)、1.41(1.14-1.74)和1.90(1.55-2.34)(趋势P:卵巢癌趋势P = 0.035,宫颈癌趋势P = 0.034)。结论:在韩国女性中,随着BMI和WC的增加,子宫内膜癌和卵巢癌的风险较肥胖前水平显著增加,而随着WC的降低,宫颈癌的风险有增加的趋势。考虑到韩国女性中肥胖相关的妇科癌症的发病率正在增加,应该加强肥胖管理,以预防肥胖相关的妇科癌症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Korean Medical Science
Journal of Korean Medical Science 医学-医学:内科
CiteScore
7.80
自引率
8.90%
发文量
320
审稿时长
3-6 weeks
期刊介绍: The Journal of Korean Medical Science (JKMS) is an international, peer-reviewed Open Access journal of medicine published weekly in English. The Journal’s publisher is the Korean Academy of Medical Sciences (KAMS), Korean Medical Association (KMA). JKMS aims to publish evidence-based, scientific research articles from various disciplines of the medical sciences. The Journal welcomes articles of general interest to medical researchers especially when they contain original information. Articles on the clinical evaluation of drugs and other therapies, epidemiologic studies of the general population, studies on pathogenic organisms and toxic materials, and the toxicities and adverse effects of therapeutics are welcome.
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