Vestibular dysfunction: a hidden risk factor for Alzheimer's disease.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology Pub Date : 2025-03-25 DOI:10.1007/s00415-025-13045-9

Carolin Anna Maria Koriath, Boris Rauchmann, Florian Schoeberl, Andreas Zwergal, Peter Falkai, Robert Perneczky

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引用次数: 0

Abstract

Background: London taxi drivers' navigationally challenged hippocampi are known to be enlarged, and reduced Alzheimer's disease (AD)-related mortality has recently been shown in similarly well-versed drivers, implying a neuroprotective effect through hippocampal engagement. Vestibular function has been linked to hippocampal size, suggesting that vestibular input may influence AD risk.

Methods: Including 16 known modifiable lifestyle factors as covariates, we analyzed UK Biobank (UKB) volunteers aged over 55 years and without dementia at baseline to assess how peripheral vestibular dysfunction (PVD) influences the likelihood of an AD diagnosis.

Results: 4684 AD and 2133 PVD cases were identified based on their ICD diagnoses; even accounting for other risk factors, PVD increased the risk of AD 1.7 times in UKB volunteers.

Discussion: Vestibular loss, linked to hippocampal atrophy and default mode network disruption, appears to increase AD risk. Consequently, active vestibular stimulation by balance training or neuromodulation could offer potential for modifying AD progression.

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来源期刊

Journal of Neurology 医学-临床神经学

CiteScore

10.00

自引率

5.00%

发文量

558

审稿时长

1 months

期刊介绍： The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.