Advances in Basivertebral Nerve Ablation for Chronic Low Back Pain: A Narrative Review.

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Sujeivan Mahendram, Paul J Christo
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引用次数: 0

Abstract

Chronic low back pain has traditionally been thought to stem from intervertebral disc degeneration. However, emerging evidence over the last few decades has revealed other contributing sources. One such etiology of chronic non-radiating axial low back pain has been attributed to vertebral end plate disruption and degeneration, leading to basivertebral nerve-mediated nociception. These degenerative events, described as Modic changes on MRI, provide a means of diagnosis and offer personalized treatment options, like minimally invasive radiofrequency ablation, to help address this source of low back pain. This review focuses on recent advancements, rationale, efficacy, and safety profile intraosseous basivertebral nerve ablation in the treatment of vertebrogenic back pain, and discusses current knowledge gaps that may help guide future research in the field.

基底神经消融治疗慢性腰痛的研究进展。
传统上认为慢性腰痛是由椎间盘退变引起的。然而,在过去的几十年里,新出现的证据揭示了其他因素。慢性非辐射性轴性腰痛的病因之一是椎体终板断裂和退变,导致椎体神经介导的伤害感受。这些退行性事件在MRI上被描述为微小的变化,为诊断提供了一种手段,并提供了个性化的治疗选择,如微创射频消融,以帮助解决这一腰痛的来源。本文综述了骨内椎体神经消融治疗椎体源性背痛的最新进展、原理、疗效和安全性,并讨论了目前的知识差距,这可能有助于指导该领域的未来研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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