Apolipoproteins in Psoriasis: The Effect of Acitretin Treatment and UVB Phototherapy.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2025-03-12 DOI:10.3390/metabo15030196

Hanna Myśliwiec, Dorota Kozłowska, Katarzyna Hodun, Bartłomiej Łukaszuk, Agnieszka Owczarczyk-Saczonek, Adrian Chabowski, Iwona Flisiak

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引用次数: 0

Abstract

Background: Psoriasis is a chronic, multi-system inflammatory disease frequently associated with metabolic syndrome and lipid disturbances. Apolipoproteins, as essential regulators of lipid metabolism, may play a critical role in these metabolic abnormalities, potentially influencing disease severity and systemic inflammation. The aim of this study was to compare serum concentrations of chosen apolipoproteins in patients with psoriasis before and after treatment with acitretin or narrowband UVB (NB-UVB).

Methods: This study was conducted on 39 patients with psoriasis. The concentration of nine apolipoproteins and C-reactive protein was quantified using the Bio-Plex Immunoassay Kit.

Results: The serum concentrations of ApoA2, ApoC1, ApoD, ApoE, and ApoJ were higher in the acitretin group compared to the NB-UVB group before treatment, while the ApoA1/ApoA2 ratio was lower. We also observed a negative association between the Psoriasis Area and Severity Index (PASI) and ApoA1/ApoA2 ratio in the patients before the treatment.

Conclusions: The results of this study confirm the presence of metabolic disturbances in psoriatic patients. The treatment with NB-UVB or acitretin did not cause any significant changes in the apolipoproteins profile. Thus, we found no detrimental impact of acitretin on the apolipoproteins profile, despite the observed rise in total cholesterol concentration after the treatment. Further research is needed to explore whether specific therapeutic approaches can modify these disturbances and potentially improve long-term cardiovascular outcomes in this population.

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载脂蛋白在银屑病中的作用：阿维素治疗和UVB光疗。

背景：银屑病是一种慢性多系统炎症性疾病，常伴有代谢综合征和脂质紊乱。载脂蛋白作为脂质代谢的重要调节因子，可能在这些代谢异常中发挥关键作用，潜在地影响疾病的严重程度和全身性炎症。本研究的目的是比较牛皮癣患者在阿维素或窄带UVB （NB-UVB）治疗前后的血清载脂蛋白浓度。方法：对39例银屑病患者进行研究。使用Bio-Plex免疫测定试剂盒定量9种载脂蛋白和c反应蛋白的浓度。结果：与NB-UVB组相比，阿维素组治疗前血清ApoA2、apo1、ApoD、ApoE、ApoJ浓度升高，ApoA1/ApoA2比值降低。我们还观察到治疗前患者的银屑病面积和严重程度指数（PASI）以及ApoA1/ApoA2比值呈负相关。结论：本研究结果证实银屑病患者存在代谢紊乱。用NB-UVB或阿维素治疗没有引起载脂蛋白谱的任何显著变化。因此，尽管观察到治疗后总胆固醇浓度升高，但我们没有发现阿维素对载脂蛋白谱的有害影响。需要进一步的研究来探索特定的治疗方法是否可以改变这些障碍，并潜在地改善这一人群的长期心血管预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.