Abnormal sperm tails correlate with the sperm DNA fragmentation index, irrespective of progressive motility, according to an analysis of 5125 semen reports.

IF 3.2 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-03-25 DOI:10.1007/s10815-025-03452-2

Yanjing Wang, Hongping Li, Minhao Hu, Xiaozhen Liu, Lejun Li

{"title":"Abnormal sperm tails correlate with the sperm DNA fragmentation index, irrespective of progressive motility, according to an analysis of 5125 semen reports.","authors":"Yanjing Wang, Hongping Li, Minhao Hu, Xiaozhen Liu, Lejun Li","doi":"10.1007/s10815-025-03452-2","DOIUrl":null,"url":null,"abstract":"Purpose: Sperm progressive motility (PR) is correlated with the sperm DNA fragmentation index (SDF). Moreover, abnormalities in sperm tails are closely associated with the quality of sperm PR. However, the correlation of abnormal sperm tails with the SDF remains unknown.Methods: Routine semen examination was performed according to the World Health Organization guidelines with a computer-assisted semen analysis system. SDF analysis was conducted via the sperm chromatin structure assay method. Spearman correlation was used to test the correlation of the SDF with age and conventional semen parameters. The relationship between the SDF and abnormal tails was explored by binary logistic regression analysis, restricted cubic spline (RCS) analyses and subgroup analysis. ROC curves were used to assess the predictive capacity of age, abnormal tails and PR for the SDF.Results: The SDF was associated with sperm morphology, with a significant correlation observed with abnormal sperm tails (r = 0.491, P < 0.001). Binary regression analysis revealed that abnormal sperm tails were an independent influencing factor of the SDF. RCS analyses and Trend analysis suggested that as the number of abnormal sperm tails increased, the risk of an abnormal SDF also increased, and the trend was statistically significant (P for trend < 0.001). The ROC curve demonstrated that abnormal sperm tails had good discriminatory ability for the SDF (AUC: 0.757, P < 0.001).Conclusion: Abnormal sperm tails are an independent influencing factor of the SDF, and a higher number of abnormal tails is associated with an increased risk of an abnormal SDF.","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Assisted Reproduction and Genetics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10815-025-03452-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Sperm progressive motility (PR) is correlated with the sperm DNA fragmentation index (SDF). Moreover, abnormalities in sperm tails are closely associated with the quality of sperm PR. However, the correlation of abnormal sperm tails with the SDF remains unknown.

Methods: Routine semen examination was performed according to the World Health Organization guidelines with a computer-assisted semen analysis system. SDF analysis was conducted via the sperm chromatin structure assay method. Spearman correlation was used to test the correlation of the SDF with age and conventional semen parameters. The relationship between the SDF and abnormal tails was explored by binary logistic regression analysis, restricted cubic spline (RCS) analyses and subgroup analysis. ROC curves were used to assess the predictive capacity of age, abnormal tails and PR for the SDF.

Results: The SDF was associated with sperm morphology, with a significant correlation observed with abnormal sperm tails (r = 0.491, P < 0.001). Binary regression analysis revealed that abnormal sperm tails were an independent influencing factor of the SDF. RCS analyses and Trend analysis suggested that as the number of abnormal sperm tails increased, the risk of an abnormal SDF also increased, and the trend was statistically significant (P for trend < 0.001). The ROC curve demonstrated that abnormal sperm tails had good discriminatory ability for the SDF (AUC: 0.757, P < 0.001).

Conclusion: Abnormal sperm tails are an independent influencing factor of the SDF, and a higher number of abnormal tails is associated with an increased risk of an abnormal SDF.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.