Alpha Lipoic Acid Supplementation and Iron Homeostasis: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

IF 2 4区医学 Q3 NUTRITION & DIETETICS

International Journal for Vitamin and Nutrition Research Pub Date : 2024-12-27 DOI:10.31083/IJVNR36623

Elham Sharifi-Zahabi, Hadi Abdollahzad

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引用次数: 0

Abstract

Background: A growing body of evidence indicates the regulating effects of alpha-lipoic acid on iron metabolism. However, findings from clinical trials are equivocal. This systematic review and meta-analysis aimed to evaluate the quantitative effect of alpha lipoic acid (ALA) supplementation on iron metabolism parameters including serum iron, total iron binding capacity, hemoglobin, and ferritin.

Methodology: Online databases, including PubMed, Scopus, and Web of Science were searched, up to 29 May 2022, to obtain all relevant studies.

Results: A total of 1901 publications were identified in the systematic search; of which, 10 studies with a total of 529 participants were included in this meta-analysis. Pooled analysis of the studies showed no statistically significant effects of ALA on ferritin (weighted mean difference (WMD) = -11.01 ng/mL; 95% CI: -40.07, 18.05 ng/mL; I² = 0.0%, p = 0.670), serum iron (WMD = -0.47 μ/dL; 95% CI: -24.48, 23.54 μ/dL; I² = 94.7%, p < 0.001), hemoglobin (WMD = 0.49 g/dL; 95% CI: -0.54, 1.52 g/dL; I² = 95.7%, p < 0.001), and total iron binding capacity (TIBC) (WMD = 3.95 μ/dL; 95% CI: -21.3, 29.2 μ/dL; I² = 53.1%, p = 0.094). In subgroup analysis, ALA significantly increased hemoglobin in patients with hematological disorders (WMD = 1.23 g/dL; 95% CI: 1.00, 1.45 g/dL; I² = 96.6%, p < 0.001) and in studies with durations longer than 8 weeks (WMD = 1.03 g/dL; 95% CI: 0.82, 1.25 g/dL; I² = 96.5%, p = 0.02).

Conclusion: ALA supplementation had no statistically significant effect on iron-related parameters. Subgroup analysis revealed a significant increasing effect of ALA on hemoglobin in patients with hematological disorders and in studies with durations >8 weeks.

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α硫辛酸补充和铁稳态：一项随机对照临床试验的综合系统评价和荟萃分析。

背景：越来越多的证据表明α -硫辛酸对铁代谢的调节作用。然而，临床试验的结果是模棱两可的。本系统综述和荟萃分析旨在评估α硫辛酸（ALA）补充对铁代谢参数（包括血清铁、总铁结合能力、血红蛋白和铁蛋白）的定量影响。方法：截至2022年5月29日，检索PubMed、Scopus和Web of Science等在线数据库，获取所有相关研究。结果：系统检索共检索到1901篇文献；其中，10项研究共纳入529名参与者。合并分析显示ALA对铁蛋白的影响无统计学意义(加权平均差(WMD) = -11.01 ng/mL；95% CI: -40.07, 18.05 ng/mL；I2 = 0.0%, p = 0.670)，血清铁(WMD = -0.47 μ/dL；95% CI: -24.48, 23.54 μ/dL；I2 = 94.7%, p < 0.001)，血红蛋白(WMD = 0.49 g/dL；95% CI: -0.54, 1.52 g/dL；I2 = 95.7%, p < 0.001)，总铁结合力（TIBC） (WMD = 3.95 μ/dL；95% CI: -21.3, 29.2 μ/dL；I2 = 53.1%, p = 0.094)。亚组分析中，ALA显著提高血液病患者血红蛋白(WMD = 1.23 g/dL；95% CI: 1.00, 1.45 g/dL；I2 = 96.6%, p < 0.001)，在持续时间超过8周的研究中(WMD = 1.03 g/dL；95% CI: 0.82, 1.25 g/dL；I2 = 96.5%, p = 0.02)。结论：补充ALA对铁相关参数无显著影响。亚组分析显示，ALA对血液病患者和持续时间为bb0 ~ 8周的研究中血红蛋白的影响显著增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal for Vitamin and Nutrition Research 医学-营养学

CiteScore

5.00

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists