Early Detection and Age-Comparative Analysis of Colorectal Cancer Screening: Insights from the Turkish Population.

IF 2.8 4区医学 Q2 ONCOLOGY

Current oncology Pub Date : 2025-03-06 DOI:10.3390/curroncol32030153

Cem Batuhan Ofluoğlu, Fırat Mülküt, İsa Caner Aydın, Mehmet Karahan

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引用次数: 0

Abstract

Background: This study aimed to evaluate the diagnostic yield of colonoscopy in asymptomatic individuals aged 45-49 years compared with those aged 50-54 years in a Turkish population, providing insights into region-specific screening strategies.

Methods: This retrospective multicenter study was conducted across three tertiary endoscopy units in Turkey. Screening colonoscopy data from 3943 asymptomatic individuals aged 45-54 years between 2018 and 2023 were analyzed. The patients were stratified into two groups: 45-49 years (Group 1) and 50-54 years (Group 2). Demographic characteristics, polyp size, histological features, and prevalence of early-onset advanced colorectal neoplasia (EAO-aCRN) were assessed.

Results: A total of 3943 patients were included, with 862 in Group 1 (45-49 years) and 3081 in Group 2 (50-54 years). The polyp detection rate was 16.6% in Group 1 and 22.9% in Group 2 (p < 0.001). The adenoma detection rates were 10.8% and 13.9% in Groups 1 and 2, respectively (p = 0.018). The advanced polyp detection rates were 3.2% and 7.3% in Groups 1 and 2, respectively (p < 0.001). Mean polyp size was 6.5 ± 5.1 mm in Group 1 and 8.8 ± 8.4 mm in Group 2 (p < 0.001). The mean number of polyps per patient was 1.5 ± 0.8 in Group 1 and 1.9 ± 1.6 in Group 2 (p = 0.023). Advanced neoplasia was detected in 16.6% of Group 1 patients compared with 22.9% of Group 2 patients (p < 0.001).

Conclusions: While CRC screening at age 45 demonstrated lower detection rates of polyps and advanced neoplasia than at age 50, the higher prevalence of EAO-CRN among 45-49-year-olds in Turkey underscores the importance of early screening in high-risk populations. Tailored regional strategies incorporating individual risk factors are crucial for optimizing CRC prevention policies.

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结直肠癌筛查的早期发现和年龄比较分析：来自土耳其人群的见解。

背景：本研究旨在评估土耳其人群中45-49岁无症状个体结肠镜检查的诊断率，并与50-54岁人群进行比较，为区域特异性筛查策略提供见解。方法：这项回顾性多中心研究在土耳其的三个三级内窥镜检查单位进行。分析了2018年至2023年间3943名45-54岁无症状个体的结肠镜筛查数据。患者被分为两组：45-49岁（第一组）和50-54岁（第二组）。评估人口统计学特征、息肉大小、组织学特征和早发性晚期结直肠肿瘤（EAO-aCRN）的患病率。结果：共纳入3943例患者，其中1组862例（45-49岁），2组3081例（50-54岁）。1组息肉检出率为16.6%，2组为22.9% （p < 0.001）。1、2组腺瘤检出率分别为10.8%、13.9% （p = 0.018）。1组和2组的晚期息肉检出率分别为3.2%和7.3% （p < 0.001）。1组平均息肉大小为6.5±5.1 mm， 2组平均息肉大小为8.8±8.4 mm （p < 0.001）。1组患者平均息肉数1.5±0.8个，2组患者平均息肉数1.9±1.6个（p = 0.023）。组1患者中有16.6%检测到晚期肿瘤，组2患者中有22.9%检测到晚期肿瘤（p < 0.001）。结论：虽然45岁CRC筛查显示息肉和晚期肿瘤的检出率低于50岁，但土耳其45-49岁人群中EAO-CRN的较高患病率强调了高危人群早期筛查的重要性。结合个体风险因素的量身定制的区域战略对于优化CRC预防政策至关重要。

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来源期刊

Current oncology ONCOLOGY-

CiteScore

3.30

自引率

7.70%

发文量

664

审稿时长

1 months

期刊介绍： Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.