Real-World Treatment Patterns, Healthcare Resource Utilization, and Healthcare Costs in the First-Line Treatment of Metastatic Non-Small Cell Lung Cancer in the US.

IF 2.8 4区 医学 Q2 ONCOLOGY
Divyan Chopra, David M Waterhouse, Ihtisham Sultan, Björn Stollenwerk
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Abstract

This study characterizes real-world treatment patterns and economic and healthcare resource utilization (HCRU) burden associated with first-line (1L) treatment of metastatic non-small cell lung cancer (NSCLC) without actionable alterations in the United States. This retrospective observational study used Optum Clinformatics® data. A total of 15,659 patients with metastatic NSCLC who started 1L treatment between January 2020 and March 2023 were included (52% male; mean age at the start of 1L treatment 71.7 years; 86% Medicare Advantage). The most frequent 1L regimens were immune checkpoint inhibitor (ICI) + platinum-based chemotherapy (PBCT) (47%), PBCT only (26%), and ICI only (20%). The median 1L treatment duration was 4.2 months (range 2.7-6.5) and was shorter with chemotherapy-only regimens. Outpatient visits accounted for the majority of HCRU (mean 6.6 visits per patient per month [PPPM]). Outpatient, inpatient, and emergency department visits were highest for chemotherapy-only regimens. Mean total (all-cause) healthcare costs were $32,215 PPPM and were highest for ICI + chemotherapy ($34,741-38,454 PPPM). Inpatient costs PPPM were highest for PBCT ($4725) and ICI + non-PBCT ($4648). First-line treatment of metastatic NSCLC without actionable alterations imposes a notable HCRU and cost burden, underscoring the need for better treatment options to improve outcomes and reduce economic impact.

美国转移性非小细胞肺癌一线治疗的现实世界治疗模式、医疗资源利用和医疗费用
本研究描述了美国转移性非小细胞肺癌(NSCLC)的一线(1L)治疗与现实世界的治疗模式、经济和医疗资源利用(HCRU)负担相关,且无可操作的改变。这项回顾性观察性研究使用了Optum Clinformatics®数据。在2020年1月至2023年3月期间开始1L治疗的转移性NSCLC患者共15,659例被纳入研究(52%男性;l治疗开始时的平均年龄为71.7岁;86% Medicare Advantage)。最常见的1L方案是免疫检查点抑制剂(ICI) +铂基化疗(PBCT)(47%),仅PBCT(26%)和仅ICI(20%)。中位1L治疗持续时间为4.2个月(范围2.7-6.5个月),单纯化疗方案的治疗时间更短。门诊就诊占HCRU的大部分(平均每个患者每月6.6次就诊[PPPM])。仅化疗方案的门诊、住院和急诊科访问量最高。平均总(全因)医疗费用为32,215 PPPM, ICI +化疗最高(34,741-38,454 PPPM)。住院费用PPPM最高的是PBCT(4725美元)和ICI +非PBCT(4648美元)。转移性非小细胞肺癌的一线治疗如果没有可操作的改变,会带来显著的HCRU和成本负担,因此需要更好的治疗方案来改善预后并减少经济影响。
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来源期刊
Current oncology
Current oncology ONCOLOGY-
CiteScore
3.30
自引率
7.70%
发文量
664
审稿时长
1 months
期刊介绍: Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.
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