Clinical Impact of MRI-Guided Intracavitary-Interstitial Brachytherapy in the Curative Management of Advanced-Stage Cervical Cancer.

IF 2.8 4区 医学 Q2 ONCOLOGY
Antje Wark, Laura Hüfner, Eva Meixner, Jan Oelmann, Laila König, Simon Höne, Katja Lindel, Jürgen Debus, Nathalie Arians
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Abstract

This study investigates the clinical efficacy of MRI-based adaptive brachytherapy (IGABT) using combined intracavitary and interstitial techniques in the curative treatment of patients with advanced cervical cancer (LACC). A retrospective analysis was conducted on 149 LACC patients treated at a single center. The therapeutic protocol included intensity-modulated external beam radiotherapy (IMRT) and IGABT. Dosimetric parameters were evaluated for relevance for local control (LC), progression-free survival (PFS), and overall survival (OS) using Kaplan-Meier estimation, Cox regression, and log-rank test. Patients predominantly presented with stage III/IV tumors (81%, FIGO 2018). The median high-risk clinical target volume (hrCTV) was 34 cm3, with a median D90% dose of 88.9 GyEQD2. At 24 months, OS, PFS, and LC rates were 86%, 57%, and 81%, respectively. FIGO stage, tumor volume, and histology were significant predictors of PFS. Higher total hrCTV doses were strongly correlated with improved LC and PFS, emphasizing the importance of precise dosimetric optimization in IGABT and confirming the critical role of IGABT in achieving very good LC rates for LACC. The reported LC rates are comparable to landmark studies, such as INTERLACE and KEYNOTE-A18. This study validates the effectiveness of MRI-guided IGABT in enhancing local tumor control in advanced-stage cervical cancer while providing insights into the prognostic implications of dosimetric parameters such as hrCTV and point A. Future research should address the persistent challenge of distant metastases by exploring the integration of novel systemic treatment options.

mri引导下腔间质内近距离放疗对晚期宫颈癌疗效的影响。
本研究探讨基于mri的适应性近距离放射治疗(IGABT)联合腔内和间质技术治疗晚期宫颈癌(LACC)的临床疗效。回顾性分析在同一中心治疗的149例LACC患者。治疗方案包括调强外束放疗(IMRT)和IGABT。使用Kaplan-Meier估计、Cox回归和log-rank检验评估剂量学参数与局部控制(LC)、无进展生存(PFS)和总生存(OS)的相关性。患者主要表现为III/IV期肿瘤(81%,FIGO 2018)。中位高危临床靶体积(hrCTV)为34 cm3,中位D90%剂量为88.9 GyEQD2。24个月时,OS、PFS和LC率分别为86%、57%和81%。FIGO分期、肿瘤体积和组织学是PFS的重要预测因子。较高的hrCTV总剂量与LC和PFS的改善密切相关,强调了精确剂量学优化在IGABT中的重要性,并证实了IGABT在达到非常好的LC率方面的关键作用。报告的LC率与INTERLACE和KEYNOTE-A18等具有里程碑意义的研究相当。本研究验证了mri引导下IGABT在加强晚期宫颈癌局部肿瘤控制方面的有效性,同时为hrCTV和a点等剂量学参数对预后的影响提供了见解。未来的研究应通过探索新的全身治疗方案的整合来解决远处转移的持续挑战。
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来源期刊
Current oncology
Current oncology ONCOLOGY-
CiteScore
3.30
自引率
7.70%
发文量
664
审稿时长
1 months
期刊介绍: Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.
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