Association Between Poor Lifestyle Habits and Cutaneous Melanoma Risk: A Mendelian Randomization Study.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S506547

Xiaohui Liu, Wenkang Luan, Shujun Fan, Tengfei Liu

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引用次数: 0

Abstract

Background: There is still no consensus on the risk factors of cutaneous melanoma, and the causal relationship between poor lifestyle habits (including undersleeping, smoking, alcohol consumption and sedentary behaviour) and cutaneous melanoma remains uncertain.

Methods: We investigated the causal effect of poor lifestyle habits on cutaneous melanoma through the Two-sample Mendelian randomization (MR). MR analysis was performed by using the genome-wide association studies (GWAS) statistics. Single-nucleotide polymorphisms (SNPs) robustly associated with undersleeping, smoking, alcohol consumption and sedentary behaviour were used as instrumental variables, we performed five MR approaches, including inverse variance weighted (IVW), weighted median, simple mode, MR-Egger and weighted mode.

Results: The causal relationship between undersleeping and cutaneous melanoma was discovered in IVW (OR = 1.018, 95% CI = 1.002-1.033, P = 0.025). However, the causal association between smoking, alcohol consumption, sedentary behaviour and cutaneous melanoma have not been found in all MR approaches.

Conclusion: The MR analysis indicated that undersleeping is causally associated with the risk of cutaneous melanoma.

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.