{"title":"Aminobisphosphonates Potentiate Non-Specific Immunological Memory.","authors":"Y Sh Schwartz, O V Semenova, A V Salmin","doi":"10.1007/s10517-025-06350-w","DOIUrl":null,"url":null,"abstract":"<p><p>Innate immune cells have the ability to acquire non-specific immunological memory (NIM), which provides resistance to a variety of bacterial and viral infections. Experiments in vitro and in vivo have verified the hypothesis that the farnesyl pyrophosphate synthase inhibitor (aminobisphosphonates) can potentiate BCG-induced NIM. The aminobisphosphonate zoledronate induced the NIM phenotype in human monocyte cultures and provided nonspecific protection against staphylococcal infection in mice. Additionally, zoledronate significantly enhanced BCG-induced NIM, resulting in a synergistic protective effect. The phenomenon of potentiation of NIM/anti-infectious resistance discovered by us can form the basis for designing powerful universal vaccines of a new type.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"427-430"},"PeriodicalIF":0.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06350-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Innate immune cells have the ability to acquire non-specific immunological memory (NIM), which provides resistance to a variety of bacterial and viral infections. Experiments in vitro and in vivo have verified the hypothesis that the farnesyl pyrophosphate synthase inhibitor (aminobisphosphonates) can potentiate BCG-induced NIM. The aminobisphosphonate zoledronate induced the NIM phenotype in human monocyte cultures and provided nonspecific protection against staphylococcal infection in mice. Additionally, zoledronate significantly enhanced BCG-induced NIM, resulting in a synergistic protective effect. The phenomenon of potentiation of NIM/anti-infectious resistance discovered by us can form the basis for designing powerful universal vaccines of a new type.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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