Comparative meta-analysis of prevalence and molecular features of high-priority Enterococcus faecium and E. faecalis from the guts of food-producing and wild birds.

IF 2.5 2区农林科学 Q1 VETERINARY SCIENCES

Avian Pathology Pub Date : 2025-03-26 DOI:10.1080/03079457.2025.2485106

Idris Nasir Abdullahi, Islem Trabelsi

{"title":"Comparative meta-analysis of prevalence and molecular features of high-priority Enterococcus faecium and E. faecalis from the guts of food-producing and wild birds.","authors":"Idris Nasir Abdullahi, Islem Trabelsi","doi":"10.1080/03079457.2025.2485106","DOIUrl":null,"url":null,"abstract":"Background: Birds harbor Enterococcus faecium and Enterococcus faecalis as gut commensals but could acquire and transmit high-priority strains.Methods: Following the PRISMA guidelines, eligible studies that reported the antimicrobial resistance (AMR) profiles of E. faecium and E. faecalis from gut samples of food-producing (FPBs) and wild birds (WBs) published from 2005 to 2024 were screened from major bibliographic databases. Random-effect models were used to determine the pooled prevalences (PPs) of vancomycin (VANR), ampicillin (AMPR), and linezolid (LZDR) resistant E. faecium and E. faecalis from non-duplicated gut samples of food-producing (FPBs) and wild birds (WBs).Results: Of the 36 eligible studies, the overall PP of VANR-E. faecium and VANR-E. faecalis were 1.8% and 0.7%, respectively. AMPR-E. faecium and AMPR-E. faecalis were 1.6% and 0.6%, respectively. LZDR-E. faecium and LZDR-E. faecalis were 1% and 0.8%, respectively. Subgroup analyses revealed significant temporal variations in the PPs of VANR-E. faecium (p < 0.05). FPBs had significantly higher PPs of VANR, AMPR and LZDR E. faecium and E. faecalis than WBs (p < 0.05). Healthcare-associated vanA-carrying E. faecium lineages from WBs (ST16, ST17, ST18, and ST412) and optrA-carrying E. faecalis lineages (ST32, ST59, ST330) from FPBs were identified. In FPBs, Egypt had the highest PP of VANR-E. faecium (11.9%) and LZDR-E. faecalis (2.8%). Conversely, the USA had the highest PP of VANR-E. faecium in WBs (2.4%).Conclusions: A higher frequency of vancomycin- than linezolid-resistant strains exists, and VANR-E. faecium are disproportionately distributed based on bird species, years of study, and countries, indicating varied selection pressure. Significantly higher prevalence of VANR-E. faecium than VANR-E. faecalis was found, highlighting the higher capacity of E. faecium to acquire ampicillin and vancomycin resistance in birds.","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-54"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avian Pathology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/03079457.2025.2485106","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Birds harbor Enterococcus faecium and Enterococcus faecalis as gut commensals but could acquire and transmit high-priority strains.

Methods: Following the PRISMA guidelines, eligible studies that reported the antimicrobial resistance (AMR) profiles of E. faecium and E. faecalis from gut samples of food-producing (FPBs) and wild birds (WBs) published from 2005 to 2024 were screened from major bibliographic databases. Random-effect models were used to determine the pooled prevalences (PPs) of vancomycin (VAN^R), ampicillin (AMP^R), and linezolid (LZD^R) resistant E. faecium and E. faecalis from non-duplicated gut samples of food-producing (FPBs) and wild birds (WBs).

Results: Of the 36 eligible studies, the overall PP of VAN^R-E. faecium and VAN^R-E. faecalis were 1.8% and 0.7%, respectively. AMP^R-E. faecium and AMP^R-E. faecalis were 1.6% and 0.6%, respectively. LZD^R-E. faecium and LZD^R-E. faecalis were 1% and 0.8%, respectively. Subgroup analyses revealed significant temporal variations in the PPs of VAN^R-E. faecium (p < 0.05). FPBs had significantly higher PPs of VAN^R, AMP^R and LZD^R E. faecium and E. faecalis than WBs (p < 0.05). Healthcare-associated vanA-carrying E. faecium lineages from WBs (ST16, ST17, ST18, and ST412) and optrA-carrying E. faecalis lineages (ST32, ST59, ST330) from FPBs were identified. In FPBs, Egypt had the highest PP of VAN^R-E. faecium (11.9%) and LZD^R-E. faecalis (2.8%). Conversely, the USA had the highest PP of VAN^R-E. faecium in WBs (2.4%).

Conclusions: A higher frequency of vancomycin- than linezolid-resistant strains exists, and VAN^R-E. faecium are disproportionately distributed based on bird species, years of study, and countries, indicating varied selection pressure. Significantly higher prevalence of VAN^R-E. faecium than VAN^R-E. faecalis was found, highlighting the higher capacity of E. faecium to acquire ampicillin and vancomycin resistance in birds.

查看原文本刊更多论文

背景：鸟类是粪肠球菌和粪肠球菌的肠道共生菌，但也可能获得和传播高危菌株：方法：按照 PRISMA 指南，从主要文献数据库中筛选出 2005 年至 2024 年间发表的符合条件的研究，这些研究报告了产粮鸟类（FPB）和野生鸟类（WB）肠道样本中的肠球菌和粪肠球菌的抗菌药耐药性（AMR）概况。采用随机效应模型确定了产粮鸟类（FPB）和野生鸟类（WB）非重复肠道样本中对万古霉素（VANR）、氨苄西林（AMPR）和利奈唑胺（LZDR）耐药的粪肠球菌和粪肠杆菌的总流行率（PPs）：在 36 项符合条件的研究中，VANR-E. faecium 和 VANR-E. faecalis 的总体 PP 分别为 1.8% 和 0.7%。AMPR-E. faecium 和 AMPR-E. faecalis 分别为 1.6% 和 0.6%。LZDR-E. faecium和LZDR-E. faecalis分别为1%和0.8%。亚组分析表明，VANR-E. faecium（p R）、AMPR 和 LZDR E. faecium 和 LZDR E. faecalis 的 PPs 与 WBs（p WBs 中携带 vanA 的 E. faecium 菌系（ST16、ST17、ST18 和 ST412）和 FPBs 中携带 optrA 的 E. faecalis 菌系（ST32、ST59 和 ST330）相比存在显著的时间差异。在 FPBs 中，埃及的 VANR-E. faecium PP（11.9%）和 LZDR-E. faecalis PP（2.8%）最高。相反，在 WBs 中，美国的 VANR-E. faecium 感染率最高（2.4%）：结论：耐万古霉素菌株的频率高于耐利奈唑胺菌株，VANR-E. faecium在鸟类种类、研究年份和国家的分布不成比例，这表明选择压力各不相同。发现VANR-E. faecium的流行率明显高于VANR-E. faecalis，这表明鸟类中的E. faecium获得氨苄西林和万古霉素耐药性的能力更强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.