Treatment expectancy and credibility as predictors of concentrated exposure treatment outcomes in patients with difficult-to-treat obsessive-compulsive disorder.

IF 3.4 2区 医学 Q2 PSYCHIATRY
Håvard Berg, Kristian Tjelle, Bjarne Hansen, Stian Solem, Thröstur Björgvinsson, Gerd Kvale, Kristen Hagen
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引用次数: 0

Abstract

Background: Treatment readiness factors, such as treatment credibility and expectancy, are postulated to be predictors of outcomes within the context of cognitive behavioral therapy (CBT). Concentrated exposure therapy (cET) is a form of short-term, intensive, exposure-based CBT that has shown promising results. This study investigated whether treatment expectancy and credibility predict cET treatment outcomes in patients with difficult-to-treat (nonresponders and patients with relapse following CBT) obsessive-compulsive disorder (OCD).

Methods: A total of 163 patients underwent 4 days of cET treatment. Treatment credibility and expectancy were measured using the Credibility/Expectancy Questionnaire (CEQ) prior to the start of treatment. OCD symptom severity was measured using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) at pretreatment, posttreatment, 3-month follow-up, and 1-year follow-up. Work- and social functioning were measured before treatment and at the 1-year follow-up.

Results: Higher CEQ scores were significantly associated with lower Y-BOCS score at posttreatment and follow-up after controlling for age, sex, and pretreatment OCD, anxiety, and depression levels. The CEQ scores were also significantly associated with work- and social functioning at the 1-year follow-up. A receiver operating characteristic analysis suggested a mean item cutoff point of 92.5 (0-100 scale) for the CEQ, and 87% of the patients classified as having high expectancy had a positive treatment response.

Conclusions: This study confirmed that treatment expectancy and credibility are predictors of cET outcomes in patients with OCD. Higher scores on the CEQ were linked to better treatment results, both immediately and up to one year later. These insights highlight the need to consider patients' attitudes toward treatment in the early treatment phase.

Trial registration: ClinicalTrials.gov identifier: NCT02656342 (First registered: 2015-11-30).

背景:治疗准备因素,如治疗可信度和期望值,被认为是认知行为疗法(CBT)结果的预测因素。集中暴露疗法(cET)是一种以暴露为基础的短期、强化 CBT,已显示出良好的效果。本研究调查了治疗期望值和可信度是否能预测难以治疗的强迫症(CBT 后无应答者和复发患者)患者的 cET 治疗结果:共有 163 名患者接受了为期 4 天的 cET 治疗。治疗开始前使用可信度/期望值问卷(CEQ)测量治疗可信度和期望值。强迫症症状的严重程度在治疗前、治疗后、3 个月随访和 1 年随访时使用耶鲁-布朗强迫症量表(Y-BOCS)进行测量。在治疗前和随访1年时对工作和社会功能进行了测量:在控制了年龄、性别以及治疗前的强迫症、焦虑症和抑郁症水平后,CEQ得分越高,治疗后和随访时的Y-BOCS得分越低。在为期一年的随访中,CEQ得分与工作和社会功能也有明显相关性。接受者操作特征分析表明,CEQ的平均项目临界点为92.5(0-100分),87%被归类为高期望值的患者对治疗有积极反应:本研究证实,治疗期望值和可信度是强迫症患者 cET 结果的预测因素。CEQ得分越高,治疗效果越好,无论是即时治疗效果还是一年后的治疗效果。这些见解强调了在早期治疗阶段考虑患者治疗态度的必要性:试验注册:ClinicalTrials.gov identifier:NCT02656342(首次注册时间:2015-11-30)。
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来源期刊
BMC Psychiatry
BMC Psychiatry 医学-精神病学
CiteScore
5.90
自引率
4.50%
发文量
716
审稿时长
3-6 weeks
期刊介绍: BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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