Fluorescence Turn-On Sensing of Leucine Using Bimetallic Cu-Ag Nanoclusters: A Potential Non-Invasive Biomarker for Cancer Detection.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-03-25 DOI:10.1021/acsabm.5c00102

Geneva Indongo, Susan Varghese, Merin K Abraham, Greeshma Rajeevan, Arathy B Kala, Dheyaa Mohammed Dhahir, Dr Sony George

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Abstract

This study investigates the use of bimetallic copper-silver nanoclusters (Cu-AgNCs) for fluorescence turn-on sensing of leucine, a potential biomarker for cancer detection. These nanoclusters exhibit high fluorescence tunability and specificity, with Fe³⁺ serving as a quencher to facilitate leucine detection. The fluorescence recovery mechanism is attributed to the interaction of leucine with Fe³⁺, alleviating the quenching effect on the metal nanoclusters. This bimetallic nanocluster is a promising platform for biomarker identification in cancer diagnosis. The fluorescence enhancement upon leucine binding provides a measurable signal, confirming the feasibility of these nanoclusters as noninvasive sensors for cancer biomarkers. The sensor achieves a detection limit of 0.58 μM and demonstrates a linear response within the range of 110-657 μM. This approach offers a promising method for noninvasive cancer diagnostics using saliva and urine samples. Additionally, the method's reproducibility and robustness further support its potential in clinical applications, providing a cost-effective and accessible technique for early cancer detection.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.