Comparative Efficacy of Various Exercise Types on Cancer-Related Fatigue for Cancer Survivors: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-03-27 DOI:10.1002/cam4.70816

Shichen Zhou, Guang Chen, Xiaoyu Xu, Cheng Zhang, Guoming Chen, Yau-Tuen Chan, Ya Xuan Sun, Jiayan Zhou, Ning Wang, Yibin Feng

{"title":"Comparative Efficacy of Various Exercise Types on Cancer-Related Fatigue for Cancer Survivors: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials","authors":"Shichen Zhou, Guang Chen, Xiaoyu Xu, Cheng Zhang, Guoming Chen, Yau-Tuen Chan, Ya Xuan Sun, Jiayan Zhou, Ning Wang, Yibin Feng","doi":"10.1002/cam4.70816","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>This study compares the effectiveness of 7 types of guideline-recommended first-line exercises for cancer-related fatigue (CRF).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A comprehensive search was conducted utilizing public databases, including Medline, Embase, Web of Science, and Cochrane Library. Randomized clinical trials examining the effects of aerobic exercise, resistance exercise, stretching exercise, combined aerobic and resistance exercise, Yoga, Qigong, or Tai Chi on CRF in various cancer types were included. A Bayesian network meta-analysis was used to synthesize the data. Subgroup analyses and sensitivity analyses were used to detect the effect modifiers and to confirm the robustness, respectively.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 33 clinical trials were included in this analysis. Overall, both resistance (SMD, −1.72; 95% CI, −2.81 to −0.63) and Yoga (SMD, −1.27; 95% CI, −1.38 to −1.16) reduced the fatigue severity significantly better than standard care, but there was no significant decrease for other exercise types. For cancer survivors with an age over 55 years, only Yoga showed statistically significant improvement in CRF (SMD, −1.27; 95% CI, −1.38 to −1.16). For patients with an age less than 55 years, both resistance (SMD, −1.75; 95% CI, −2.91 to −0.58) and Yoga (SMD, −1.66; 95% CI, −2.81 to −0.51) reduced the fatigue severity compared to standard care.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Both resistance exercise and yoga showed significant benefits in alleviating CRF compared to standard care. Yoga was particularly effective for cancer survivors over 55 years of age, while resistance exercise and yoga were comparably effective for those under 55 years.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 7","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70816","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cam4.70816","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

This study compares the effectiveness of 7 types of guideline-recommended first-line exercises for cancer-related fatigue (CRF).

Methods

A comprehensive search was conducted utilizing public databases, including Medline, Embase, Web of Science, and Cochrane Library. Randomized clinical trials examining the effects of aerobic exercise, resistance exercise, stretching exercise, combined aerobic and resistance exercise, Yoga, Qigong, or Tai Chi on CRF in various cancer types were included. A Bayesian network meta-analysis was used to synthesize the data. Subgroup analyses and sensitivity analyses were used to detect the effect modifiers and to confirm the robustness, respectively.

Results

A total of 33 clinical trials were included in this analysis. Overall, both resistance (SMD, −1.72; 95% CI, −2.81 to −0.63) and Yoga (SMD, −1.27; 95% CI, −1.38 to −1.16) reduced the fatigue severity significantly better than standard care, but there was no significant decrease for other exercise types. For cancer survivors with an age over 55 years, only Yoga showed statistically significant improvement in CRF (SMD, −1.27; 95% CI, −1.38 to −1.16). For patients with an age less than 55 years, both resistance (SMD, −1.75; 95% CI, −2.91 to −0.58) and Yoga (SMD, −1.66; 95% CI, −2.81 to −0.51) reduced the fatigue severity compared to standard care.

Conclusion

Both resistance exercise and yoga showed significant benefits in alleviating CRF compared to standard care. Yoga was particularly effective for cancer survivors over 55 years of age, while resistance exercise and yoga were comparably effective for those under 55 years.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.