Social cognition in mild cognitive impairment and dementia: A systematic review and meta-analysis

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-03-27 DOI:10.1002/alz.70076

Puyu Shi, Hannah Chapman, Lisa Liu, Fern Rodgers, Jasmine Shaw, Gill Livingston, Katherine P. Rankin, Jason D. Warren, Andrew Sommerlad

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引用次数: 0

Abstract

Social cognition is impaired in people with dementia but the differences in social cognitive impairment between mild cognitive impairment (MCI) and dementia and its subtypes remain unclear. We therefore aimed to systematically review and meta-analyze differences in emotion recognition, theory of mind (ToM), and empathy between individuals with MCI and dementia. Across 28 cross-sectional studies (n = 2409), people with MCI had better emotion recognition (Cohen's d = 0.69) and ToM (d = 0.70) than individuals with Alzheimer's disease (AD) dementia, and larger effect sizes were observed for people with frontotemporal dementia (FTD) (emotion recognition (d = 2.09), ToM (d = 1.49), but emotional empathy was higher in AD than in MCI in included studies. Our findings suggest a progressive decline of aspects of social cognition across the MCI–dementia continuum. Longitudinal studies should investigate the diagnostic role of social cognition deficits in MCI progression to dementia, and interventions for social cognition in MCI should be developed and tested.

Highlights

First systematic review and meta-analysis comparing social cognition between mild cognitive impairment (MCI) and dementia subtypes.
Findings from 28 studies with 2409 participants show people with MCI outperform those with Alzheimer's disease (AD) and frontotemporal dementia (FTD) in emotion recognition and theory of mind.
Empathy appears intact in AD dementia, suggesting that this cognitive domain is preserved throughout disease progression.
Evaluation of social cognition should be built into dementia assessment as it may hold diagnostic value.

Abstract Image

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痴呆症患者的社会认知能力会受损，但轻度认知障碍（MCI）与痴呆症及其亚型之间的社会认知障碍差异仍不清楚。因此，我们旨在对 MCI 和痴呆症患者在情感识别、心智理论（ToM）和移情方面的差异进行系统回顾和元分析。在28项横断面研究（n = 2409）中，MCI患者的情绪识别能力（Cohen's d = 0.69）和心智理论（ToM）（d = 0.70）均优于阿尔茨海默病（AD）痴呆症患者，额颞叶痴呆症（FTD）患者的效应大小更大（情绪识别能力（d = 2.09）和心智理论（ToM）（d = 1.49）），但在纳入的研究中，AD患者的情感共鸣高于MCI患者。我们的研究结果表明，在 MCI-痴呆症的连续过程中，社会认知的各个方面会逐渐下降。纵向研究应探讨社会认知缺陷在 MCI 发展为痴呆症过程中的诊断作用，并应开发和测试针对 MCI 社会认知的干预措施。研究重点首次对轻度认知障碍（MCI）和痴呆症亚型的社会认知进行系统回顾和荟萃分析。来自28项研究、2409名参与者的研究结果显示，MCI患者在情感识别和心智理论方面优于阿尔茨海默病（AD）和额颞叶痴呆症（FTD）患者。移情能力在阿兹海默病痴呆症患者中似乎完好无损，这表明这一认知领域在疾病进展过程中始终得以保留。对社会认知的评估应纳入痴呆症评估中，因为它可能具有诊断价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.