Driving research on successful aging and neuroprotection in Latin America: Insights from the inaugural symposium on brain resilience and healthy longevity

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-03-27 DOI:10.1002/alz.70037

Yakeel T. Quiroz, David Aguillón, Joseph Arboleda-Velasquez, Yamile Bocanegra, Gloria Patricia Cardona-Gómez, Maria M. Corrada, Ibai Diez, Elkin Garcia-Cifuentes, Kenneth Kosik, Lusiana Martinez, David Pineda-Salazar, Rafael Posada, Norbel Roman, Diego Sepulveda-Falla, Andrea Slachevsky, Marcio Soto-Añari, Evelyn Tabilo, Daniel Vasquez, Andrés Villegas-Lanau

{"title":"Driving research on successful aging and neuroprotection in Latin America: Insights from the inaugural symposium on brain resilience and healthy longevity","authors":"Yakeel T. Quiroz, David Aguillón, Joseph Arboleda-Velasquez, Yamile Bocanegra, Gloria Patricia Cardona-Gómez, Maria M. Corrada, Ibai Diez, Elkin Garcia-Cifuentes, Kenneth Kosik, Lusiana Martinez, David Pineda-Salazar, Rafael Posada, Norbel Roman, Diego Sepulveda-Falla, Andrea Slachevsky, Marcio Soto-Añari, Evelyn Tabilo, Daniel Vasquez, Andrés Villegas-Lanau","doi":"10.1002/alz.70037","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Global life expectancy has steadily increased in recent decades, resulting in a significant rise in the number of individuals aged 80 years and older. This trend is also evident in Latin America, where life expectancy is improving, though at varying rates across countries and regions.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Partnering with the Neurosciences Group of Antioquia (GNA), we launched a Colombian study on resilience in families with autosomal dominant Alzheimer's disease and the oldest-old population. Over the past 2 years, the project has expanded to include participants from Peru, Chile, and Costa Rica.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>This research led to the first symposium on Brain Resilience and Healthy Longevity, held in Medellín, Colombia, in August 2024.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>The article summarizes key discussions from the symposium, highlighting the most promising opportunities for brain resilience and prevention research in the region and offering recommendations for future research to promote healthy aging and dementia-free communities.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Uncovering the genetic and physiological drivers of cognitive resilience, neurodegeneration resistance, and healthy longevity is essential for maintaining brain function as we age.</li>\n \n <li>“Superagers” and cognitively resilient individuals from Latin American families with Alzheimer's disease offer valuable insights into brain protection mechanisms.</li>\n \n <li>Studying the interplay of socio-environmental and genetic factors in the oldest-old is key to understanding healthy longevity and improving dementia prevention.</li>\n \n <li>The inaugural Brain Resilience and Healthy Longevity Symposium highlights the need for global collaboration to uncover factors that drive cognitive resilience and healthy aging in Latin America, advancing dementia prevention.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 3","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70037","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70037","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

Global life expectancy has steadily increased in recent decades, resulting in a significant rise in the number of individuals aged 80 years and older. This trend is also evident in Latin America, where life expectancy is improving, though at varying rates across countries and regions.

METHODS

Partnering with the Neurosciences Group of Antioquia (GNA), we launched a Colombian study on resilience in families with autosomal dominant Alzheimer's disease and the oldest-old population. Over the past 2 years, the project has expanded to include participants from Peru, Chile, and Costa Rica.

RESULTS

This research led to the first symposium on Brain Resilience and Healthy Longevity, held in Medellín, Colombia, in August 2024.

DISCUSSION

The article summarizes key discussions from the symposium, highlighting the most promising opportunities for brain resilience and prevention research in the region and offering recommendations for future research to promote healthy aging and dementia-free communities.

Highlights

Uncovering the genetic and physiological drivers of cognitive resilience, neurodegeneration resistance, and healthy longevity is essential for maintaining brain function as we age.
“Superagers” and cognitively resilient individuals from Latin American families with Alzheimer's disease offer valuable insights into brain protection mechanisms.
Studying the interplay of socio-environmental and genetic factors in the oldest-old is key to understanding healthy longevity and improving dementia prevention.
The inaugural Brain Resilience and Healthy Longevity Symposium highlights the need for global collaboration to uncover factors that drive cognitive resilience and healthy aging in Latin America, advancing dementia prevention.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.