Reza Shafiei, Amir Azimian, Mahdi Mohebali, Zahra Badiei, Nima Firouzeh, Saber Raeghi
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引用次数: 0
Abstract
Porpuse
Human visceral leishmaniasis (HVL) is a severe form of leishmaniasis caused by protozoan parasites of the genus Leishmania.
Methods
From 2013 to 2022, this study, molecular diagnosis was conducted on 50 pediatric bone marrow aspiration samples from northeast Iran, all of which had previously been confirmed to have visceral leishmaniasis. The ITS-rDNA gene and phylogenetic analysis were performed.
Results
The results revealed that 49 samples tested positive for L. infantum species, whereas 1 sample was identified as L. major. All three L. infantum isolates showed similar haplotypes, whereas the L. major isolate exhibited nucleotide differences in the sequence analyzed.
Conclusion
It could be concluded that visceral manifestations of cutaneous leishmaniasis in children living in endemic areas should be considered a contributing factor to the development of HVL. The present study provides a relatively comprehensive snapshot of unusual leishmania species status that could be responsible for HVL development.
期刊介绍:
Acta Parasitologica is an international journal covering the latest advances in the subject.
Acta Parasitologica publishes original papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in biochemical and molecular biology of parasites, their physiology, morphology, taxonomy and ecology, as well as original research papers on immunology, pathology, and epidemiology of parasitic diseases in the context of medical, veterinary and biological sciences. The journal also publishes short research notes, invited review articles, book reviews.
The journal was founded in 1953 as "Acta Parasitologica Polonica" by the Polish Parasitological Society and since 1954 has been published by W. Stefanski Institute of Parasitology of the Polish Academy of Sciences in Warsaw. Since 1992 in has appeared as Acta Parasitologica in four issues per year.