Nanoparticle-based radiosensitization strategies in nuclear medicine: current status and future directions

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-02-21 DOI:10.1007/s10967-025-10010-8

Baydaa Taher Sih, Abdulrahman T. Ahmed, Mahmood Jawad, Hussein Riyadh Abdul Kareem Al-Hetty, MM Rekha, Pradeep Soothwal, K. Satyam Naidu, Renu Arya, Yasser Fakri Mustafa, Munthar Kadhim Abosaoda

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引用次数: 0

Abstract

Radiosensitization approaches have shown promise in enhancing the therapeutic efficacy of radiation in nuclear medicine. This review article focuses on using nanoparticles (NPs) as radiosensitizers in nuclear medicine applications. This review covers various NP-based radiosensitization mechanisms, such as increasing radiation-induced DNA damages, alternation and modulation of tumor microenvironment, and improving radionuclide delivery efficiency. We also discussed about the challenges and opportunities of NP radiosensitization in clinical practice. Our review showed that NP-based radiosensitization strategies can result in important advancements in nuclear medicine and therefore improve cancer treatments. Despite these advancements in NP radiosensitization strategies, there are several challenges that limit their application in clinical practice. Therefore, continued research is needed to address key challenges in oncology. The future of NP radiosensitization strategies in nuclear medicine looks promising, with potential therapeutic options. This article tried to provide insights into the current status, challenges, and future perspective of NP-based radiosensitization strategies in nuclear medicine treatments.

Graphical Abstract

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核医学中基于纳米粒子的放射增敏策略：现状与未来方向

放射增敏方法在提高核医学放射治疗效果方面显示出希望。本文综述了纳米颗粒作为放射性增敏剂在核医学中的应用。本文综述了各种基于np的放射致敏机制，如增加辐射诱导的DNA损伤，肿瘤微环境的改变和调节，以及提高放射性核素的递送效率。我们还讨论了NP放射增敏在临床实践中的挑战和机遇。我们的综述表明，基于np的放射增敏策略可以导致核医学的重要进步，从而改善癌症治疗。尽管NP放射增敏策略取得了这些进展，但仍有一些挑战限制了它们在临床实践中的应用。因此，需要继续研究以解决肿瘤学中的关键挑战。核医学中NP放射增敏策略的未来看起来很有希望，具有潜在的治疗选择。本文试图就核医学治疗中基于np的放射增敏策略的现状、挑战和未来展望提供一些见解。图形抽象

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.