Nanoparticle-based radiosensitization strategies in nuclear medicine: current status and future directions

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-02-21 DOI:10.1007/s10967-025-10010-8

Baydaa Taher Sih, Abdulrahman T. Ahmed, Mahmood Jawad, Hussein Riyadh Abdul Kareem Al-Hetty, MM Rekha, Pradeep Soothwal, K. Satyam Naidu, Renu Arya, Yasser Fakri Mustafa, Munthar Kadhim Abosaoda

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引用次数: 0

Abstract

Radiosensitization approaches have shown promise in enhancing the therapeutic efficacy of radiation in nuclear medicine. This review article focuses on using nanoparticles (NPs) as radiosensitizers in nuclear medicine applications. This review covers various NP-based radiosensitization mechanisms, such as increasing radiation-induced DNA damages, alternation and modulation of tumor microenvironment, and improving radionuclide delivery efficiency. We also discussed about the challenges and opportunities of NP radiosensitization in clinical practice. Our review showed that NP-based radiosensitization strategies can result in important advancements in nuclear medicine and therefore improve cancer treatments. Despite these advancements in NP radiosensitization strategies, there are several challenges that limit their application in clinical practice. Therefore, continued research is needed to address key challenges in oncology. The future of NP radiosensitization strategies in nuclear medicine looks promising, with potential therapeutic options. This article tried to provide insights into the current status, challenges, and future perspective of NP-based radiosensitization strategies in nuclear medicine treatments.

Graphical Abstract

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.