Polymeric mixed micelles with triple stimuli-responsive characteristics and förster resonance energy transfer phenomenon for drug delivery system of chemotherapy and photodynamic therapy
{"title":"Polymeric mixed micelles with triple stimuli-responsive characteristics and förster resonance energy transfer phenomenon for drug delivery system of chemotherapy and photodynamic therapy","authors":"Hong-Jia Lin, Li-Xuan Hong, Wen-Chung Wu","doi":"10.1007/s10965-025-04327-x","DOIUrl":null,"url":null,"abstract":"<div><p>In recent years, chemotherapy has been used in cancer treatment commonly. However, the hydrophobic property and non-selective apoptosis still limit its application. Recently, drug delivery systems (DDS) such as polymer micelles, liposomes, and dendrimers have been widely developed to improve the efficiency of chemotherapy. In this work, the amphiphilic polymer was used to encapsulate the Doxorubicin (DOX) through the self-assembly process to form the polymer micelles, and the drug release of DOX was controlled by the temperature-sensitive monomer (triethylene glycol methyl ether methacrylate, TEGMA) and redox-responsive group (disulfide bond, S–S). On the other hand, the intracellular internalization was improved by the photosensitizer drug (protoporphyrin IX, PpIX) through the photochemical internalization (PCI) process. The lower critical solution temperature (LCST) of micelles in this work was 37.6 °C, and the in-vitro test showed that 96% of DOX was released under acid conditions with the high level of redox agent. Finally, the chemotherapy was confirmed by the cytotoxicity assays and confocal laser scanning microscope (CLSM).</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":658,"journal":{"name":"Journal of Polymer Research","volume":"32 4","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymer Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10965-025-04327-x","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
In recent years, chemotherapy has been used in cancer treatment commonly. However, the hydrophobic property and non-selective apoptosis still limit its application. Recently, drug delivery systems (DDS) such as polymer micelles, liposomes, and dendrimers have been widely developed to improve the efficiency of chemotherapy. In this work, the amphiphilic polymer was used to encapsulate the Doxorubicin (DOX) through the self-assembly process to form the polymer micelles, and the drug release of DOX was controlled by the temperature-sensitive monomer (triethylene glycol methyl ether methacrylate, TEGMA) and redox-responsive group (disulfide bond, S–S). On the other hand, the intracellular internalization was improved by the photosensitizer drug (protoporphyrin IX, PpIX) through the photochemical internalization (PCI) process. The lower critical solution temperature (LCST) of micelles in this work was 37.6 °C, and the in-vitro test showed that 96% of DOX was released under acid conditions with the high level of redox agent. Finally, the chemotherapy was confirmed by the cytotoxicity assays and confocal laser scanning microscope (CLSM).
期刊介绍：
Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology.
As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including:
polymer synthesis;
polymer reactions;
polymerization kinetics;
polymer physics;
morphology;
structure-property relationships;
polymer analysis and characterization;
physical and mechanical properties;
electrical and optical properties;
polymer processing and rheology;
application of polymers;
supramolecular science of polymers;
polymer composites.
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