Effects of antibiotics and heavy metals on ARGs in Danjiangkou Reservoir

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Emerging Contaminants Pub Date : 2025-03-20 DOI:10.1016/j.emcon.2024.100453

Jing Li , Xuanzi Guo , Xingxing Long , Jiangyan Wu , Weijia Zhang , Yanrong Zhu , Chunhui Xi , Yao Zhang

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引用次数: 0

Abstract

Antibiotic resistance genes (ARGs) have attracted more and more attention due to their potential exposure hazards. The Danjiangkou Reservoir (DJKR) is the source of water for the Middle Route Project under the South-to-North Water Transfer Scheme in China. To clarify the distribution of ARGs and their influencing factors in DJKR (including Danjiang Reservoir (DR) and Hanjiang River Reservoir (HR)), we used metagenomic analysis to investigate the ARGs. The results showed that the most abundant bacteria of both parts were Proteobacteteria. Antibiotic efflux (58.2 %) and alteration of antibiotic targets (69.4 %) were the main mechanisms in DR and HR. The composition of ARG species was similar in the two parts, but the number of ARG isoforms in HR was significantly higher than that in DR. ARG Intl1 was detected in both DR and HR. Network analysis showed a significant correlation between mobile genetic elements (MGEs) and ARGs. Heavy metals also showed a significant correlation with ARGs. Interestingly, the relationship between heavy metals and ARGs were more significant than that between antibiotics and ARGs.

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来源期刊

Emerging Contaminants Medicine-Public Health, Environmental and Occupational Health

CiteScore

10.00

自引率

6.70%

发文量

审稿时长

44 days

期刊介绍： Emerging Contaminants is an outlet for world-leading research addressing problems associated with environmental contamination caused by emerging contaminants and their solutions. Emerging contaminants are defined as chemicals that are not currently (or have been only recently) regulated and about which there exist concerns regarding their impact on human or ecological health. Examples of emerging contaminants include disinfection by-products, pharmaceutical and personal care products, persistent organic chemicals, and mercury etc. as well as their degradation products. We encourage papers addressing science that facilitates greater understanding of the nature, extent, and impacts of the presence of emerging contaminants in the environment; technology that exploits original principles to reduce and control their environmental presence; as well as the development, implementation and efficacy of national and international policies to protect human health and the environment from emerging contaminants.