Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in oral lichen planus patients with vitamin B12 deficiency

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-01-18 DOI:10.1016/j.jds.2025.01.007

Yu-Hsueh Wu , Julia Yu-Fong Chang , Yi-Pang Lee , Yi-Ping Wang , Andy Sun , Chun-Pin Chiang

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引用次数: 0

Abstract

Background/purpose

Our previous study found that 60 of 588 oral lichen planus (OLP) patients have vitamin B12 deficiency. This study assessed whether the vitamin B12-deficient OLP (B12D/OLP) patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects and evaluated whether all B12D/OLP patients had pernicious anemia (PA).

Materials and methods

The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 60 B12D/OLP patients and 588 healthy control subjects were measured and compared.

Results

We found that 60 B12D/OLP patients had significantly lower mean blood Hb and serum iron, vitamin B12, and folic acid levels as well as significantly higher mean corpuscular volume (MCV) and mean serum homocysteine level than 588 healthy control subjects (all P-values <0.01). Moreover, 60 B12D/OLP patients had significantly higher frequencies of macrocytosis (55.0 %), blood Hb (68.3 %) and serum iron (31.7 %) and vitamin B12 (100.0 %) deficiencies, hyperhomocysteinemia (91.7 %), and serum GPCA positivity (66.7 %) than 588 healthy control subjects (all P-values <0.001). The four most common types of anemia in 41 anemic B12D/OLP patients were PA (17 patients, 41.5 %), normocytic anemia (12 patients, 29.3 %), iron deficiency anemia (6 patients, 14.6 %), and macrocytic anemia other than PA (5 patients, 12.2 %).

Conclusion

The B12D/OLP patients have significantly higher frequencies of macrocytosis, blood Hb and serum iron and vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects. Only 17 (28.3 %) of 60 B12D/OLP patients have PA.

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维生素B12缺乏症口腔扁平苔藓患者贫血、血凝素缺乏、高同型半胱氨酸血症和血清胃壁细胞抗体阳性

背景/目的我们之前的研究发现588例口腔扁平苔藓（OLP）患者中有60例缺乏维生素B12。本研究评估维生素b12缺乏性OLP （B12D/OLP）患者的贫血、血凝素缺乏症、高同型半胱氨酸血症和血清胃壁细胞抗体（GPCA）阳性的频率是否明显高于健康对照组，并评估是否所有B12D/OLP患者都有恶性贫血（PA）。材料与方法测定60例B12D/OLP患者与588例健康对照者的血红蛋白（Hb）、血清铁、维生素B12、叶酸、同型半胱氨酸、GPCA水平。结果60例B12D/OLP患者的平均血Hb和血清铁、维生素B12、叶酸水平显著低于588例健康对照者，平均红细胞体积（MCV）和平均血清同型半胱氨酸水平显著高于588例健康对照者（p值均为0.01）。此外，60例B12D/OLP患者出现巨噬细胞增多（55.0%）、血Hb（68.3%）、血清铁（31.7%）和维生素B12（100.0%）缺乏、高同型半胱氨酸血症（91.7%）和血清GPCA阳性（66.7%）的频率显著高于588例健康对照（p值均为0.001）。41例B12D/OLP贫血患者中最常见的4种贫血类型为PA（17例，41.5%）、正红细胞贫血（12例，29.3%）、缺铁性贫血（6例，14.6%）和PA以外的大细胞贫血（5例，12.2%）。结论B12D/OLP患者巨噬细胞增多、血Hb、血清铁和维生素B12缺乏症、高同型半胱氨酸血症、血清GPCA阳性发生率明显高于健康对照组。60例B12D/OLP患者中只有17例（28.3%）有PA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.