Albumin fouling-free electrochemical sensors based on polyaniline single walled carbon nanotube composites for precise purine metabolomics

IF 6.5 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Composites Communications Pub Date : 2025-03-21 DOI:10.1016/j.coco.2025.102363

Thenmozhi Rajarathinam , Sivaguru Jayaraman , Devaraju Subramani , Suraj Aswale , Jaewon Lee , Hyun-jong Paik , Chang-Seok Kim , Jang-Hee Yoon , Seung-Cheol Chang

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引用次数: 0

Abstract

Electrochemical sensors enable rapid and accurate detection of targets. However, fouling is a burden that restricts sensor performance in complex biofluids and fouling resistant or fouling-free property is paramount to guarantee the reliable operation of sensors. Single-walled carbon nanotubes (SWCNTs) possess an exceptional catalytic capability owing to the weak molecular adsorption of sp3 carbon. Poly(aniline-N-propane sulfonic acid) (PAPS) polymer dispersed SWCNTs with a high conductivity (4.184 S/cm), and hydrophilicity were prepared to circumvent the fouling issues. The length of the PAPS dispersed SWCNTs were 3.1 ± 1.0 μm and the modified screen-printed carbon electrodes (PAPS-SWCNTs/SPCEs) demonstrated efficient electro-oxidation of purines, such as, uric acid (UA), xanthine (XA), and hypoxanthine (HX) after exposure to high concentrations of a common foulant, serum albumin. The peak-to-peak separations of UA–XA, XA–HX, and UA–HX were 0.396 V, 0.352 V, and 0.748 V, respectively. The detection limits of UA, XA, and HX were 0.047, 0.049, and 0.052 μM respectively. The practical applicability of the sensor was established using human serum and synthetic urine samples. The fabricated sensor is fouling-free and could serve as a potential diagnostic device for the early detection of renal diseases, such as renal calculi, chronic kidney diseases, and renal failure in resource-limited settings, since it does not require scrupulous sample pretreatment, frequent recalibration or prolonged waiting times. Moreover, the developed sensor adheres to ASSURED criteria, which is crucial for the diagnosis of renal diseases in resource-limited settings.

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来源期刊

Composites Communications Materials Science-Ceramics and Composites

CiteScore

12.10

自引率

10.00%

发文量

340

审稿时长

36 days

期刊介绍： Composites Communications (Compos. Commun.) is a peer-reviewed journal publishing short communications and letters on the latest advances in composites science and technology. With a rapid review and publication process, its goal is to disseminate new knowledge promptly within the composites community. The journal welcomes manuscripts presenting creative concepts and new findings in design, state-of-the-art approaches in processing, synthesis, characterization, and mechanics modeling. In addition to traditional fiber-/particulate-reinforced engineering composites, it encourages submissions on composites with exceptional physical, mechanical, and fracture properties, as well as those with unique functions and significant application potential. This includes biomimetic and bio-inspired composites for biomedical applications, functional nano-composites for thermal management and energy applications, and composites designed for extreme service environments.