Silicon-based fluorescent drug delivery composites based on silver nanowires for non-small cell lung cancer therapy

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-03-21 DOI:10.1016/j.matlet.2025.138444

Yi Zhu , Lianghong Ying , Hui Hui , Lingling Zhu , Hongyan Niu

引用次数: 0

Abstract

Lung cancer, particularly non-small cell lung cancer (NSCLC), remains a major cause of cancer-related death due to late diagnosis and limited treatment options. This study developed a novel composite, PCL-APTES-ZnS@AgNWs@Afatinib, to improve drug delivery. Silver nanowires (AgNWs) were synthesized and integrated into a PCL-ZnS matrix functionalized with APTES for enhanced biocompatibility and drug loading. Characterization confirmed successful synthesis. In vitro, the composite effectively encapsulated Afatinib, inhibited SF3B4 expression, and suppressed NSCLC cell proliferation. This system combines PCL’s biodegradability, APTES functionalization, and AgNWs’ bioactivity, offering a robust platform for controlled, targeted drug delivery with potential for enhanced antitumor efficacy in NSCLC.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive