Validation of Item 4 of the Neurological disorders depression Inventory for epilepsy as a rapid screening tool for suicidality in Russian persons with epilepsy

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-03-26 DOI:10.1016/j.yebeh.2025.110392

Sofya Popova , Mikhail Zinchuk , Georgii Kustov , Flora Rider , Alla Guekht

{"title":"Validation of Item 4 of the Neurological disorders depression Inventory for epilepsy as a rapid screening tool for suicidality in Russian persons with epilepsy","authors":"Sofya Popova , Mikhail Zinchuk , Georgii Kustov , Flora Rider , Alla Guekht","doi":"10.1016/j.yebeh.2025.110392","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Suicide rates among persons with epilepsy (PWE) are high and a reliable and valid tool to screen for suicidality in this population is needed. The aim of this study is to validate the Russian version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Item 4 as a screening tool for suicidality in PWE.</div></div><div><h3>Methods</h3><div>A consecutive sample of the Russian PWE has completed the NDDI-E. The Columbia Suicide Severity Rating Scale (C-SSRS) was used as the gold standard for assessing suicide risk. Statistical methods used were Fisher’s exact test, Mann-Whitney test and Benjamini-Hochberg procedure. Item 4 characteristics for suicide screening were evaluated using receiver operating characteristics (ROC) analysis, and the maximum value of Youden’s index (J) was used to select the optimal cut-off point.</div></div><div><h3>Results</h3><div>A total of 372 PWE were enrolled (mean age 42.9 years, 64.8 % female), of whom 42 (11.3 %) were at risk for suicide. The area under the curve (AUC) for Item 4 in identifying suicide risk was 0.86 and the optimal cut-off for Item 4 was > 1 (J = 0.661). At this cut-off, Item 4 had a sensitivity of 80.9 %, a specificity of 85.1 %, a positive predictive value (PPV) of 41.0 % and a negative predictive value (NPV) of 97.2 %.</div></div><div><h3>Conclusion</h3><div>Item 4 of the Russian version of the NDDI-E (with a cut-off of > 1) is a reliable and valid tool for screening suicidality in PWE. It has good psychometric properties, is not time-consuming, and could therefore be recommended for routine use in settings providing medical care to Russian-speaking PWE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"167 ","pages":"Article 110392"},"PeriodicalIF":2.3000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epilepsy & Behavior","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1525505025001313","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Suicide rates among persons with epilepsy (PWE) are high and a reliable and valid tool to screen for suicidality in this population is needed. The aim of this study is to validate the Russian version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Item 4 as a screening tool for suicidality in PWE.

Methods

A consecutive sample of the Russian PWE has completed the NDDI-E. The Columbia Suicide Severity Rating Scale (C-SSRS) was used as the gold standard for assessing suicide risk. Statistical methods used were Fisher’s exact test, Mann-Whitney test and Benjamini-Hochberg procedure. Item 4 characteristics for suicide screening were evaluated using receiver operating characteristics (ROC) analysis, and the maximum value of Youden’s index (J) was used to select the optimal cut-off point.

Results

A total of 372 PWE were enrolled (mean age 42.9 years, 64.8 % female), of whom 42 (11.3 %) were at risk for suicide. The area under the curve (AUC) for Item 4 in identifying suicide risk was 0.86 and the optimal cut-off for Item 4 was > 1 (J = 0.661). At this cut-off, Item 4 had a sensitivity of 80.9 %, a specificity of 85.1 %, a positive predictive value (PPV) of 41.0 % and a negative predictive value (NPV) of 97.2 %.

Conclusion

Item 4 of the Russian version of the NDDI-E (with a cut-off of > 1) is a reliable and valid tool for screening suicidality in PWE. It has good psychometric properties, is not time-consuming, and could therefore be recommended for routine use in settings providing medical care to Russian-speaking PWE.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.