A dual-site HD-tDCS of the left inferior frontal gyrus and inferior parietal lobe modulates picture-word naming performance in healthy individuals

IF 2 3区心理学 Q3 BEHAVIORAL SCIENCES

Neuropsychologia Pub Date : 2025-03-23 DOI:10.1016/j.neuropsychologia.2025.109135

Mingjing Bao, Bin Xuan

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引用次数: 0

Abstract

The selection of appropriate lexical entries constitutes a crucial stage in the process of speech production. The theories of lexical choice competition and the hypothesis of response exclusion both propose that inhibitory control might play a significant role in handling cognitive conflicts arising from lexical selection. Previous studies have utilized transcranial direct current stimulation (tDCS) to enhance speech function in individuals by primarily targeting stimulation on the left inferior frontal gyrus (IFG). However, the effects of this intervention have been inconsistent in healthy individuals. In this study, we apply tDCS successively to both the left inferior frontal gyrus (IFG) and the left inferior parietal lobe (IPL) of healthy individuals, along with picture naming training. We aim to investigate the potential enhancement of word production performance in healthy individuals through a combined intervention targeting verbal functioning and inhibitory control. The experimental findings indicated that speech training in isolation did not have a significant impact on picture-word interference performance. Furthermore, it was observed that speech training in healthy individuals only showed an effect when combined with stimulation of two specific brain regions. However, this effect varied depending on the type of interfering word. The findings of this study support the lexical selection and generation require the involvement of inhibitory control, and provide an analysis of the phenomenon of unstable effects of tDCS applied to left IFG in healthy individuals. Additionally, new insights are provided for the clinical application of tDCS in treating speech dysfunction.

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左侧额下回和顶叶下回的双位置HD-tDCS调节健康个体的图片-单词命名能力

词汇的选择是语音生成过程中的一个重要环节。词汇选择竞争理论和反应排斥假说都认为抑制控制可能在处理词汇选择引起的认知冲突中发挥重要作用。以往的研究利用经颅直流电刺激（tDCS）来增强个体的语言功能，主要针对左侧额下回（IFG）的刺激。然而，这种干预的效果在健康个体中并不一致。在本研究中，我们将tDCS先后应用于健康个体的左侧额下回（IFG）和左侧顶叶下回（IPL），并进行图片命名训练。我们的目的是通过针对言语功能和抑制控制的联合干预来研究健康个体单词生成性能的潜在增强。实验结果表明，孤立的语音训练对图像-文字干扰表现没有显著影响。此外，研究还发现，健康个体的语言训练只有在同时刺激两个特定的大脑区域时才有效果。然而，这种影响取决于干扰词的类型。本研究结果支持词汇选择和生成需要抑制控制的参与，并分析了tDCS应用于健康个体左IFG的不稳定效应现象。为tDCS治疗语言功能障碍的临床应用提供了新的见解。

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来源期刊

Neuropsychologia 医学-行为科学

CiteScore

5.10

自引率

3.80%

发文量

228

审稿时长

4 months

期刊介绍： Neuropsychologia is an international interdisciplinary journal devoted to experimental and theoretical contributions that advance understanding of human cognition and behavior from a neuroscience perspective. The journal will consider for publication studies that link brain function with cognitive processes, including attention and awareness, action and motor control, executive functions and cognitive control, memory, language, and emotion and social cognition.