Complex respiratory effects of nebulised citric acid and capsaicin as tussive agents: A comparative study in conventional and specific pathogen-free guinea pigs

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2025-03-24 DOI:10.1016/j.resp.2025.104417

Tomas Buday , Mariana Brozmanova , Janka Jakusova , Zuzana Biringerova , Lukas Martvon , Jana Plevkova

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引用次数: 0

Abstract

Background

Citric acid and capsaicin are commonly used in cough research due to their reproducible effects on animal models and humans. However, these extend beyond cough provocation.

Objective

To characterize and describe the respiratory responses to citric acid and capsaicin exposure using whole-body plethysmography in conventional (CON) and specific pathogen-free (SPF) guinea pigs.

Methods

Male and female guinea pigs were exposed to aerosols of saline, citric acid (0.4 M), and capsaicin (25 µM). Cough and respiratory parameters (inspiratory and expiratory time, respiratory rate, tidal volume, enhanced pause and mid-expiratory flow) were recorded.

Results

Both tussive agents induced upper and lower airway responses besides cough, with significant differences in respiratory parameters between CON and SPF animals. Citric acid elicited a stronger upper airway response compared to capsaicin.

Conclusion

Citric acid and capsaicin trigger complex respiratory responses (bronchoconstriction, braking, breathing pattern changes). These findings highlight the need to consider broader respiratory responses in translational cough research.

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.