Black phosphorene-enhanced Raman spectroscopy for sensitive detection of DNA nucleotides

IF 3.5 2区物理与天体物理 Q2 PHYSICS, APPLIED

Applied Physics Letters Pub Date : 2025-03-25 DOI:10.1063/5.0264525

Ferdinand Nouaye, Mohammed Amlieh, Soukayna Boulaassafre, Younes Akabli, Sidi Abdelmajid Ait Abdelkader, Afaf Yaden, Vivek Chaudhary, Reda Ben Mrid, Rachid El Fatimy, Abdelouahad El Fatimy

引用次数: 0

Abstract

In this study, we propose black phosphorene (BP) for surface-enhanced Raman spectroscopy of DNA nucleotides. BP-enhanced Raman spectroscopy provides superior enhancement compared to other 2D materials, such as graphene and molybdenum disulfide, for biomolecular detection. We show that BP significantly amplifies the Raman signals of DNA nucleotides, enabling more sensitive and accurate detection of individual nucleotides. This enhancement may be attributed to the strong charge transfer with biomolecules and anisotropic structure, which increases molecular dipole moments when positioned on its surface. These factors lead to stronger molecular interactions and improved Raman signal sensitivity. Our findings highlight BP as a promising platform for biosensor applications, paving the way for more precise biomolecular sensing and advanced diagnostics.

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来源期刊

Applied Physics Letters 物理-物理：应用

CiteScore

6.40

自引率

10.00%

发文量

1821

审稿时长

1.6 months

期刊介绍： Applied Physics Letters (APL) features concise, up-to-date reports on significant new findings in applied physics. Emphasizing rapid dissemination of key data and new physical insights, APL offers prompt publication of new experimental and theoretical papers reporting applications of physics phenomena to all branches of science, engineering, and modern technology. In addition to regular articles, the journal also publishes invited Fast Track, Perspectives, and in-depth Editorials which report on cutting-edge areas in applied physics. APL Perspectives are forward-looking invited letters which highlight recent developments or discoveries. Emphasis is placed on very recent developments, potentially disruptive technologies, open questions and possible solutions. They also include a mini-roadmap detailing where the community should direct efforts in order for the phenomena to be viable for application and the challenges associated with meeting that performance threshold. Perspectives are characterized by personal viewpoints and opinions of recognized experts in the field. Fast Track articles are invited original research articles that report results that are particularly novel and important or provide a significant advancement in an emerging field. Because of the urgency and scientific importance of the work, the peer review process is accelerated. If, during the review process, it becomes apparent that the paper does not meet the Fast Track criterion, it is returned to a normal track.