Pregnancy and postpartum dynamics revealed by millions of lab tests

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-03-26 DOI:10.1126/sciadv.adr7922

Alon Bar, Ron Moran, Netta Mendelsohn-Cohen, Yael Korem Kohanim, Avi Mayo, Yoel Toledano, Uri Alon

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Abstract

Pregnancy and delivery involve dynamic alterations in many physiological systems. However, the physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human population. Here, we present the dynamics of 76 lab tests based on a cross-sectional analysis of 44 million measurements from over 300,000 pregnancies. We analyzed each test at weekly intervals from 20 weeks preconception to 80 weeks postpartum, providing detailed temporal profiles. About half of the tests take 3 months to a year to return to baseline postpartum, highlighting the physiological load of childbirth. The precision of the data revealed effects of preconception supplements, overshoots after delivery and intricate temporal responses to changes in blood volume and renal filtration rate. Pregnancy complications—gestational diabetes, preeclampsia, and postpartum hemorrhage—showed distinct dynamical changes. These results provide a comprehensive dynamic portrait of the systems physiology of pregnancy.

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妊娠和分娩涉及许多生理系统的动态变化。然而，目前还没有对大量人群在怀孕期间和分娩后的生理动态进行高时间分辨率的系统分析。在此，我们基于对来自 30 多万名孕妇的 4400 万次测量数据的横截面分析，介绍了 76 项实验室测试的动态变化。从怀孕前 20 周到产后 80 周，我们每周对每项检测进行分析，从而提供了详细的时间曲线。大约有一半的测试在产后需要 3 个月到 1 年的时间才能恢复到基线，这凸显了分娩的生理负荷。数据的精确性揭示了孕前补充剂的影响、产后过冲以及对血量和肾滤过率变化的复杂时间反应。妊娠并发症--妊娠糖尿病、子痫前期和产后出血--显示出明显的动态变化。这些结果为妊娠系统生理学提供了全面的动态描述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.