Implanted Magnetoelectric Bionic Cartilage Hydrogel

IF 27.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2025-03-26 DOI:10.1002/adma.202415417

Jiachen Liang, Xinyue Huang, Kaiqi Qin, Hui Wei, Jiaxin Yang, Bin Liu, Zengjie Fan

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Abstract

Enhancing defective cartilage repair by creating a bionic cartilage hydrogel supplemented with in situ electromagnetic stimulation, replicating endogenous electromagnetic effects, remains challenging. To achieve this, a unique three-phase solvent system is designed to prepare a magnetoelectric bionic cartilage hydrogel incorporating piezoelectric poly(3-hydroxybutyric acid-3-hydroxyvaleric acid) (PHBV) and magnetostrictive triiron tetraoxide nanoparticles (Fe₃O₄ NPs) into sodium alginate (SA) hydrogel to form a dual-network, semi-crosslinked chain entanglement structure. The synthesized hydrogel features similar composition, structure, and mechanical properties to natural cartilage. In addition, after the implantation of cartilage, the motion-driven magnetoelectric-coupled cyclic transformation model is triggered by gentle joint forces, initiating a piezoelectric response that leads to magnetoelectric-coupled cyclic transformation. The freely excitable and cyclically enhanced electromagnetic stimulation it can provide, by simulating and amplifying endogenous electromagnetic effects, obtains induced defective cartilage repair efficacy superior to piezoelectric or magnetic stimulation alone.

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植入磁电仿生软骨水凝胶

通过制造一种仿生软骨水凝胶来增强缺陷软骨的修复，并辅以原位电磁刺激，复制内源性电磁效应，仍然具有挑战性。为了实现这一目标，设计了一种独特的三相溶剂体系，将压电聚（3-羟基丁酸-3-羟基戊酸）（PHBV）和磁致伸缩四氧化三铁纳米粒子（Fe3O4 NPs）结合到海藻酸钠（SA）水凝胶中，制备出一种磁电仿生软骨水凝胶，形成双网络、半交联链纠缠结构。合成的水凝胶具有与天然软骨相似的组成、结构和力学性能。此外，软骨植入后，关节的温和力触发运动驱动的磁电耦合循环转化模型，产生压电响应，导致磁电耦合循环转化。它所能提供的可自由激发和循环增强的电磁刺激，通过模拟和放大内源性电磁效应，获得优于单独压电或磁刺激的诱导缺损软骨修复效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.