Recent advances in nanomaterials for integrated phototherapy and immunotherapy

IF 20.3 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews Pub Date : 2025-03-25 DOI:10.1016/j.ccr.2025.216608

Zhuqing Sun , Nannan Wang , Yelin Wu , Shihui Wen , Dayong Jin

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引用次数: 0

Abstract

The integration of immunotherapy with phototherapy represents a synergistic approach, combining the localized effects of nanomaterial-enabled phototherapy with systemic immune activation to achieve comprehensive therapeutic outcomes. Nanomaterials enhance light-based therapies through superior photon conversion, efficient drug delivery, and co-delivery of immune adjuvants, thereby amplifying immune responses and addressing the limitations of traditional treatments. This review highlights recent advancements in the design, classification, and application of nanomaterials for integrated phototherapy and immunotherapy. Key topics include innovative nanomaterials systems, therapeutic models, and imaging techniques that improve precision and efficacy. Despite significant progress, challenges remain in optimizing nanomaterial biocompatibility, delivery efficiency, and immune modulation. Looking ahead, the development of multifunctional nanomaterials and deeper understanding of their synergistic mechanisms hold immense potential to transform precision medicine, paving the way for innovative and highly effective therapeutic strategies.

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免疫疗法与光疗的结合是一种协同方法，它将纳米材料光疗的局部效应与全身免疫激活相结合，从而达到全面的治疗效果。纳米材料通过卓越的光子转换、高效的药物输送和免疫佐剂的共同输送来增强光基疗法，从而扩大免疫反应并解决传统疗法的局限性。本综述重点介绍了用于综合光疗和免疫疗法的纳米材料在设计、分类和应用方面的最新进展。主要内容包括创新的纳米材料系统、治疗模型以及可提高精确度和疗效的成像技术。尽管取得了重大进展，但在优化纳米材料的生物相容性、传输效率和免疫调节方面仍存在挑战。展望未来，多功能纳米材料的开发和对其协同机制的深入了解将为精准医学的变革带来巨大潜力，为创新和高效的治疗策略铺平道路。

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.