Is there a link between choroidal and retinal parameters in patients with systemic sclerosis? A prospective study

IF 3.1 3区 医学 Q2 ONCOLOGY
Aleksandra Leoniuk , Barbara Pieklarz , Ewa Gińdzieńska-Sieśkiewicz , Anna Szwedowicz , Iwona Obuchowska , Otylia Kowal-Bielecka , Joanna Konopińska , Diana A. Dmuchowska
{"title":"Is there a link between choroidal and retinal parameters in patients with systemic sclerosis? A prospective study","authors":"Aleksandra Leoniuk ,&nbsp;Barbara Pieklarz ,&nbsp;Ewa Gińdzieńska-Sieśkiewicz ,&nbsp;Anna Szwedowicz ,&nbsp;Iwona Obuchowska ,&nbsp;Otylia Kowal-Bielecka ,&nbsp;Joanna Konopińska ,&nbsp;Diana A. Dmuchowska","doi":"10.1016/j.pdpdt.2025.104568","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>Systemic sclerosis (SSc) is an autoimmune connective tissue disease. It affects choroid causing reduction in its thickness and volume. The aim of this study has been to get a better insight into the pathogenesis of retinal and choroidal involvement in SSc.</div></div><div><h3>Methods</h3><div>This prospective single-center cross-sectional study included 33 patients with SSc and 40 controls. A full ophthalmological and rheumatological assessment was performed. The patients underwent the spectral-domain optical coherence tomography. The thickness of the inner retinal and outer retinal layer (ORL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) was evaluated, as well as the central macular choroidal thickness and choroidal vascularity index (CVI).</div></div><div><h3>Results</h3><div>The inner retinal thickness did not differ. In the outer retina, slight differences were observed in the thickness of the RPE and ORL within the inner temporal subfield, that were thinner in SSc patients, p&lt;0.05. Choroidal parameters differed between the groups (luminal, stromal, and total choroidal areas; central choroidal thickness, p&lt;0.05 for all). Correlations were found in the SSc patients (diffuse cutaneous systemic sclerosis group: the central macular ORL with the CVI rho=0.47, p=0.042; limited cutaneous systemic sclerosis group: the central macular RPE thickness with the total choroidal area rho=-0,7, p=0038, and with the luminal area: rho=-0,7, p=0036). The univariate regression analyses revealed only few significant associations with low fit of models to the data of the central macular ORL, ONL, RPE with the tested ocular and clinical parameters in the SSc and the controls.</div></div><div><h3>Conclusion</h3><div>It is plausible to assume that, although reduced in the SSc patients, the choroidal blood supply to the outer retina may still be sufficient to maintain its thickness.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104568"},"PeriodicalIF":3.1000,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572100025000973","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose

Systemic sclerosis (SSc) is an autoimmune connective tissue disease. It affects choroid causing reduction in its thickness and volume. The aim of this study has been to get a better insight into the pathogenesis of retinal and choroidal involvement in SSc.

Methods

This prospective single-center cross-sectional study included 33 patients with SSc and 40 controls. A full ophthalmological and rheumatological assessment was performed. The patients underwent the spectral-domain optical coherence tomography. The thickness of the inner retinal and outer retinal layer (ORL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) was evaluated, as well as the central macular choroidal thickness and choroidal vascularity index (CVI).

Results

The inner retinal thickness did not differ. In the outer retina, slight differences were observed in the thickness of the RPE and ORL within the inner temporal subfield, that were thinner in SSc patients, p<0.05. Choroidal parameters differed between the groups (luminal, stromal, and total choroidal areas; central choroidal thickness, p<0.05 for all). Correlations were found in the SSc patients (diffuse cutaneous systemic sclerosis group: the central macular ORL with the CVI rho=0.47, p=0.042; limited cutaneous systemic sclerosis group: the central macular RPE thickness with the total choroidal area rho=-0,7, p=0038, and with the luminal area: rho=-0,7, p=0036). The univariate regression analyses revealed only few significant associations with low fit of models to the data of the central macular ORL, ONL, RPE with the tested ocular and clinical parameters in the SSc and the controls.

Conclusion

It is plausible to assume that, although reduced in the SSc patients, the choroidal blood supply to the outer retina may still be sufficient to maintain its thickness.
系统性硬化症患者脉络膜和视网膜参数之间是否存在联系?一项前瞻性研究。
目的:系统性硬化症(SSc)是一种自身免疫性结缔组织疾病。它影响脉络膜,使其厚度和体积减少。本研究的目的是为了更好地了解SSc中视网膜和脉络膜受累的发病机制。方法:本前瞻性单中心横断面研究纳入33例SSc患者和40例对照。进行了全面的眼科和风湿病学评估。患者行光谱域光学相干断层扫描。检测视网膜内外层(ORL)、外核层(ONL)、视网膜色素上皮(RPE)厚度,以及黄斑中央脉络膜厚度和脉络膜血管指数(CVI)。结果:视网膜内厚度无明显差异。外视网膜的RPE和ORL在颞内亚场的厚度上有细微的差异,SSc患者的RPE和ORL的厚度更薄。结论:虽然SSc患者的RPE和ORL的厚度减少了,但我们有理由认为,SSc患者的脉络膜血供可能仍然足以维持其厚度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.80
自引率
24.20%
发文量
509
审稿时长
50 days
期刊介绍: Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信