The effect of Arabic gum on gentamycin nephrotoxicity in mice: a pathological study.

Q2 Medicine

Medicinski Glasnik Pub Date : 2025-01-01 DOI:10.17392/1845-22-01

Liqaa Khalel Alhyali, Firas Mohammed Abed, Entisar Rahem Al-Kenanny

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引用次数: 0

Abstract

Aim: To investigate the effect of Arabic gum on gentamycin nephrotoxicity in mice kidney.

Methods: Forty (40) mice were divided into five groups, eight mice in each. Group one (G1) stands for the negative control group. The second one (G2) was injected with gentamycin only, while the third one (G3) was given an Arabic gum orally 10g/kg. The 4th group (G4) was injected with gentamycin for 8 days, and then followed by Arabic gum orally for 8 days. The fifth group (G5) was injected with gentamycin plus oral administration of Arabic gum at the same time. A scoring system (+1-+4) was used to grade the histological features in the kidneys.

Results: The results revealed a significant increase in body weight in G3 group only; this group presented a significant decrease in the level of both urea and creatinine. Group G2 showed a marked elevation in both serum urea and creatinine. Acute tubular necrosis (+4), in both G2 and G5. In G3, kidney sections presented mild cell swelling of the tubular epithelium in addition to the normal architectures (score +1), while G4 sections revealed tubular hyalin cast, expansion of glomerular tufts.

Conclusion: The research indicates that gentamycin leads to kidney damage in mice. Arabic gum could be a treatment option although additional studies are required to determine the best dosing and timing, for optimal effectiveness.

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目的：研究阿拉伯树胶对小鼠肾脏中庆大霉素肾毒性的影响：将 40 只小鼠分为 5 组，每组 8 只。第一组（G1）为阴性对照组。第二组（G2）只注射庆大霉素，第三组（G3）口服阿拉伯树胶 10 克/公斤。第四组（G4）注射庆大霉素 8 天，然后口服阿拉伯树胶 8 天。第五组（G5）在注射庆大霉素的同时口服阿拉伯树胶。采用评分系统（+1-+4）对肾脏组织学特征进行评分：结果表明，只有 G3 组的体重明显增加，尿素和肌酐水平明显下降。G2 组的血清尿素和肌酐均明显升高。G2 和 G5 组均出现急性肾小管坏死（+4）。在 G3 组中，肾脏切片除显示正常结构外，还显示肾小管上皮细胞轻度肿胀（+1 分），而 G4 组切片显示肾小管透明质铸型、肾小球束扩张：研究表明，庆大霉素会导致小鼠肾脏损伤。阿拉伯树胶可以作为一种治疗选择，但还需要更多的研究来确定最佳剂量和时间，以达到最佳效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinski Glasnik 医学-医学：内科

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Medicinski Glasnik (MG) is the official publication (two times per year) of the Medical Association of Zenica-Doboj Canton. Manuscripts that present of original basic and applied research from all fields of medicine (general and clinical practice, and basic medical sciences) are invited.