Collagen fiber and cellular dynamics of axolotl skin with aging.

IF 1.7 4区 生物学 Q4 CELL BIOLOGY
Chisaki Shima, Ayaka Ohashi, Saya Furukawa, Sakiya Yamamoto, Rena Kashimoto, Akira Satoh
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Abstract

As skin ages, its structure and function undergo significant transformations driven by complex cellular and molecular processes. In this study, we explore these changes using the axolotl, an amphibian model known for its transparent skin, allowing detailed observation of both epidermal and dermal layers. We found that axolotl skin, composed of an epidermis and a collagen-rich dermis with three distinct layers (stratum baladachinum, spongiosum, and compactum), shows clear age-related alterations. These changes include reduced fibroblast numbers, altered lattice-patterned cell morphology, disruption of the lattice patterned collagen fiber pattern, thickening the stratum spongiosum, and thinning of the stratum compactum. Notably, fibroblasts, which play a crucial role in collagen braiding, displayed diminished functionality in older axolotls. This study highlights how aging affects both the structural integrity of dermal collagen and cellular dynamics. Given the similarity between axolotl and mammalian skin, these findings may provide valuable insights into the mechanisms of skin aging and potential avenues for anti-aging therapies. This research offers a foundation for future studies aimed at understanding skin aging and regeneration.

老化时蝾螈皮肤的胶原纤维与细胞动力学。
随着皮肤老化,其结构和功能在复杂的细胞和分子过程的驱动下发生重大转变。在这项研究中,我们使用美西螈(一种以其透明皮肤而闻名的两栖动物模型)来探索这些变化,从而可以详细观察表皮和真皮层。我们发现,由表皮和富含胶原蛋白的真皮层组成的美西螈皮肤有三层(baladachinum层、海绵状层和紧实层),显示出明显的年龄相关变化。这些变化包括成纤维细胞数量减少,晶格型细胞形态改变,晶格型胶原纤维模式破坏,海绵层增厚,致密层变薄。值得注意的是,在胶原蛋白编织中起关键作用的成纤维细胞在年老的蝾螈中显示出功能减弱。这项研究强调了衰老如何影响真皮胶原蛋白的结构完整性和细胞动力学。鉴于美西螈和哺乳动物皮肤的相似性,这些发现可能为皮肤衰老的机制和抗衰老治疗的潜在途径提供有价值的见解。这项研究为未来的研究提供了基础,旨在了解皮肤老化和再生。
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来源期刊
Development Growth & Differentiation
Development Growth & Differentiation 生物-发育生物学
CiteScore
4.60
自引率
4.00%
发文量
62
审稿时长
6 months
期刊介绍: Development Growth & Differentiation (DGD) publishes three types of articles: original, resource, and review papers. Original papers are on any subjects having a context in development, growth, and differentiation processes in animals, plants, and microorganisms, dealing with molecular, genetic, cellular and organismal phenomena including metamorphosis and regeneration, while using experimental, theoretical, and bioinformatic approaches. Papers on other related fields are also welcome, such as stem cell biology, genomics, neuroscience, Evodevo, Ecodevo, and medical science as well as related methodology (new or revised techniques) and bioresources. Resource papers describe a dataset, such as whole genome sequences and expressed sequence tags (ESTs), with some biological insights, which should be valuable for studying the subjects as mentioned above. Submission of review papers is also encouraged, especially those providing a new scope based on the authors’ own study, or a summarization of their study series.
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