A Review and Meta-Analysis on Altered Brain Structure in Patients Born with Non-Syndromic Cleft Lip and/or Palate.

IF 1.1 4区医学 Q2 Dentistry

Cleft Palate-Craniofacial Journal Pub Date : 2025-03-24 DOI:10.1177/10556656251327526

N N Homoud, A J Ireland, M Sherriff, Z AlSaffar, A J V Davies, J R Sandy

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引用次数: 0

Abstract

ObjectiveTo determine if there is evidence for a relationship between the presence of a non-syndromic cleft lip and/or palate (NSCL/P) and altered brain structure in cleft affected individuals.DesignElectronic database (MEDLINE; EMBASE; Cochrane library) and manual searches were performed and were limited to English language texts published between 1st of January 1969 until 1st of June 2024. Data extraction and risk of bias assessment were carried out independently by two reviewers. A meta-analysis on 9 publications was performed using a random effects model.Main outcome measureComparison of brain structure between patients born with cleft lip and/or palate and unaffected healthy individuals.ResultsThe review identified 11 studies, of which 9 were included in the meta-analysis. The latter comprised 398 individuals with NSCL/P compared to 458 unaffected controls. There was statistical evidence to suggest a reduction in the overall intracranial volume and the total cerebellar volume in the NSCL/P cases compared to the controls (Hedges' g and 95% confidence intervals: -0.36 [95% CI: -0.65, -0.08] and -0.69 [95% CI: -0.84, -0.53], respectively). For the cortical gray matter, straight gyrus, and total cerebral volume, there was no statistical evidence to suggest a difference between the NSCL/P cases and the controls.ConclusionIn individuals with NSCL/P, the overall intracranial volume and the total cerebellar volume were both smaller than in unaffected controls.

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先天性非综合征性唇腭裂患者脑结构改变的回顾和荟萃分析。

目的确定是否有证据表明非综合征性唇裂和/或腭裂（NSCL/P）的存在与唇裂患者大脑结构的改变之间存在关系。设计通过电子数据库（MEDLINE；EMBASE；Cochrane图书馆）和人工检索，仅限于1969年1月1日至2024年6月1日期间发表的英文文献。数据提取和偏倚风险评估由两名审稿人独立完成。采用随机效应模型对 9 篇文献进行了荟萃分析。主要结果测量比较先天性唇裂和/或腭裂患者与未受影响的健康人的大脑结构。后者包括 398 名 NSCL/P 患者和 458 名未受影响的对照者。有统计证据表明，与对照组相比，NSCL/P 患者的颅内总容积和小脑总容积有所减少（Hedges' g 和 95% 置信区间分别为：-0.36 [95% CI: -0.65, -0.08] 和 -0.69 [95% CI: -0.84, -0.53]）。结论 NSCL/P 患者的颅内总体积和小脑总体积均小于未受影响的对照组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cleft Palate-Craniofacial Journal DENTISTRY, ORAL SURGERY & MEDICINE-SURGERY

CiteScore

2.20

自引率

36.40%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cleft Palate-Craniofacial Journal (CPCJ) is the premiere peer-reviewed, interdisciplinary, international journal dedicated to current research on etiology, prevention, diagnosis, and treatment in all areas pertaining to craniofacial anomalies. CPCJ reports on basic science and clinical research aimed at better elucidating the pathogenesis, pathology, and optimal methods of treatment of cleft and craniofacial anomalies. The journal strives to foster communication and cooperation among professionals from all specialties.