Suppressive effects of lemon myrtle extract against the colonization and virulence factors of Candida spp.

Abstract

Objectives

Candida species (Candida spp.) are among the most common opportunistic pathogens inhabiting the oral cavity and frequently cause infection in immunocompromised individuals. Conventional antibiotic treatments for Candida infections face significant challenges, including the emergence of antimicrobial resistance. This highlights the urgent need for alternative therapeutic strategies, particularly those leveraging natural products.

Methods

In this study, we evaluated the inhibitory effects of an aqueous lemon myrtle extract on the colonization and virulence of six Candida spp., including microbial adhesion, biofilm formation, extracellular polysaccharide production, hyphal production, and several invasion-associated virulence factors.

Results

The extract significantly reduced Candida adhesion to hard surfaces and inhibited biofilm formation. Additionally, it suppressed the production of insoluble extracellular polysaccharides and various invasion-associated virulence factors, including phospholipase, ergosterol, protease, and hyphal formation.

Conclusions

These findings provide a better understanding of the potential role of lemon myrtle extract as a natural therapeutic agent for controlling Candida colonization and mitigating its invasive capabilities. This study provides a foundation for further exploration of lemon myrtle as a promising alternative for the management of Candida infections.