Residual gastric cancer with a mixed small cell neuroendocrine and keratinizing squamous cell carcinoma: A case report.

IF 2.6 Q3 ONCOLOGY

World journal of clinical oncology Pub Date : 2025-03-24 DOI:10.5306/wjco.v16.i3.102301

Tian Wang, Yang Cheng, Fan Hu, Qiang Wang

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引用次数: 0

Abstract

Background: Despite advancements in early detection and treatment, the prognosis and histological types for residual gastric cancer (GC) remains poor.

Case summary: This case report presents a rare occurrence of residual GC featuring a combination of small cell neuroendocrine carcinoma (SCNEC) and squamous cell carcinoma (SCC) in a 60-year-old male patient. The patient, with a history of Billroth II gastrectomy for duodenal ulcer bleeding, presented with gastrointestinal bleeding. Preoperative computed tomography and positron emission tomography-computed tomography indicated adenocarcinoma with tumor and abdominal lymph node metastasis. The patient underwent laparoscopic total gastrectomy and lymph node dissection for residual GC. Histological examination of the resected tumor confirmed the presence of both SCNEC and SCC. Postoperatively, the patient underwent adjuvant chemotherapy four times. Two years later, the patient was found to occur esophageal cancer and was performed a small bowel stoma and radical esophagectomy.

Conclusion: In this case report, we detail a rare instance of residual GC with mixed SCNEC and SCC, emphasizing the complexity of diagnosis and treatment, and the need for ongoing research.

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残余胃癌合并混合小细胞神经内分泌和角化鳞状细胞癌1例。

背景：病例摘要：本病例报告了一名60岁男性患者的罕见残留胃癌，其特征是小细胞神经内分泌癌（SCNEC）和鳞状细胞癌（SCC）的合并。该患者曾因十二指肠溃疡出血行比洛斯II胃切除术，术后出现消化道出血。术前计算机断层扫描和正电子发射计算机断层扫描显示为腺癌，肿瘤和腹腔淋巴结转移。患者接受了腹腔镜全胃切除术和淋巴结清扫术，以清除残留的胃癌。切除肿瘤的组织学检查证实了 SCNEC 和 SCC 的存在。术后，患者接受了四次辅助化疗。两年后，患者被发现患有食管癌，并接受了小肠造口术和根治性食管切除术：在本病例报告中，我们详细介绍了一例罕见的残留 GC 混合 SCNEC 和 SCC 的病例，强调了诊断和治疗的复杂性以及持续研究的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of clinical oncology ONCOLOGY-

自引率

0.00%

发文量

585

期刊介绍： The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.