Mother-to-child transmission of hepatitis B in Far North Queensland, 2013-2023.

Q3 Medicine
Josh Hanson, Sharna Radlof, Jenna Coffman, Kathy Lort-Phillips, Simon Smith, Allison Hempenstall, Annie Preston-Thomas
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Abstract

Background: With optimal antenatal and perinatal care and immunisation, the risk of perinatal transmission of hepatitis B virus (HBV) approaches zero. However, it can be logistically challenging to deliver this care to culturally and linguistically diverse populations and to those individuals who are living in remote Australian communities. This study examined the management of pregnant women with chronic hepatitis B (CHB) and their children in Far North Queensland (FNQ). It was hoped that this would identify the successes and limitations of the current FNQ HBV programme which was established in June 2017.

Methods: We used the Queensland notifiable diseases register to identify every female of childbearing age (13-45 years) living in FNQ with CHB during the study period 1 January 2013 - 31 December 2023. We identified the children born to these women during the study period and assessed whether their care was concordant with current Australian HBV management guidelines.

Results: We identified 261 women of childbearing age who had 148 live births during the study period: 93/148 children (63%) were born to First Nations Australian mothers; 58/148 (39%) were born to mothers who were born overseas; and 46/148 (31%) were born to mothers who lived in remote locations. After establishment of the FNQ HBV programme, 71/77 pregnancies (92%) had optimal antenatal HBV care; 71/77 (92%) had optimal perinatal HBV care; and 72/77 infants (94%) had complete HBV vaccination. There have been no children confirmed to be hepatitis B surface antigen (HBsAg) positive since the establishment of the FNQ HBV programme. However, only 70/148 children (47%) have had HBsAg testing.

Conclusions: Antenatal and perinatal care and infant vaccination is currently concordant with national HBV guidelines in > 90% of pregnancies in the FNQ region. There has been no confirmed mother-to-child HBV transmission since establishment of a local HBV programme, although improved child testing is necessary to substantiate this finding.

背景:通过最佳的产前和围产期护理及免疫接种,围产期传播乙型肝炎病毒(HBV)的风险接近于零。然而,要为不同文化和语言的人群以及生活在澳大利亚偏远社区的人提供这种护理服务,在后勤方面可能会面临挑战。本研究调查了远北昆士兰(FNQ)地区慢性乙型肝炎(CHB)孕妇及其子女的管理情况。我们希望通过这项研究来确定当前 FNQ HBV 计划(该计划于 2017 年 6 月建立)的成功之处和局限性:我们利用昆士兰州应报告疾病登记册,确定了在 2013 年 1 月 1 日至 2023 年 12 月 31 日研究期间居住在 FNQ 的每一位患有慢性乙型肝炎的育龄女性(13-45 岁)。我们确定了这些女性在研究期间所生的孩子,并评估了她们的护理是否符合澳大利亚现行的 HBV 管理指南:我们确定了 261 名育龄妇女,她们在研究期间生育了 148 名活产婴儿:93/148(63%)名婴儿由澳大利亚原住民母亲所生;58/148(39%)名婴儿由海外出生的母亲所生;46/148(31%)名婴儿由居住在偏远地区的母亲所生。原住民区乙型肝炎病毒计划制定后,71/77 名孕妇(92%)获得了最佳产前乙型肝炎病毒护理;71/77 名孕妇(92%)获得了最佳围产期乙型肝炎病毒护理;72/77 名婴儿(94%)接种了乙型肝炎病毒疫苗。自 FNQ HBV 计划实施以来,没有儿童被确认为乙型肝炎表面抗原 (HBsAg) 阳性。然而,只有 70/148 名儿童(47%)接受过 HBsAg 检测:结论:在 FNQ 地区,产前和围产期保健以及婴儿疫苗接种目前符合国家 HBV 指南的比例超过 90%。自当地建立 HBV 计划以来,没有发生过经证实的母婴 HBV 传播,但有必要改进儿童检测以证实这一结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
72
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