Incidence of Adverse Drug Reactions Among HIV Patients on Antiretroviral Drugs in Ethiopia: A Systematic Review and Meta-Analysis.

IF 1.1 Q4 INFECTIOUS DISEASES
AIDS Research and Treatment Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI:10.1155/arat/8820274
Simachew Getaneh Endalamew, Solomon Keflie Assefa, Milkiyas Solomon Getachew, Fetlework Gubena Arage, Dejen Kahsay Asgedom, Bewuketu Terefe, Destaw Fetene Teshome
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引用次数: 0

Abstract

Introduction: In recent decades, AIDS-related illnesses have declined due to the widespread use of highly active antiretroviral therapy (HAART). Despite the numerous benefits that HAART provides, it causes significant challenges for users in the form of adverse drug reactions (ADRs). Therefore, this systematic review and meta-analysis was conducted to explore the pooled incidence of antiretroviral therapy-related adverse drugs in Ethiopia. Methods: A systematic review and meta-analysis was conducted on cohort studies conducted among HIV patients living in Ethiopia. The study was reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A random-effects meta-analysis was used to determine the pooled incidence of ADR. Heterogeneity was assessed, and the source of variation was analyzed using subgroup and sensitivity analyses. Funnel plots and Egger's regression tests were used to investigate publication bias. Results: Based on the random effects model from 10 extracted studies, the pooled incidence rate of adverse effects of ART drugs was 5.09 (95% CI: 3.86-6.71) per 100 person-years, with significant heterogeneity (I 2 = 96.4%, p < 0.0001). It was also observed to be higher in subgroups from multicenter study areas, studies employing both prospective and retrospective designs, and among children. Discussion: The findings of this systematic review and meta-analysis revealed disparities in ADR incidence rates. In addition, the findings of this review showed that the occurrence of ART-related ADR in people living with HIV is common in the healthcare system. Conclusion: This systematic review and meta-analysis highlighted the significant incidence of adverse effects among individuals diagnosed with HIV in ART clinics in Ethiopia. A comprehensive strategy and coordinated collaboration among health planners, policymakers, and the community are essential to address this issue and integrate pharmacovigilance into service provision.

埃塞俄比亚服用抗逆转录病毒药物的艾滋病患者中药物不良反应的发生率:系统回顾与元分析》。
导言:近几十年来,由于高效抗逆转录病毒疗法(HAART)的广泛使用,与艾滋病相关的疾病有所减少。尽管 HAART 带来了诸多益处,但它也以药物不良反应(ADR)的形式给使用者带来了巨大挑战。因此,本系统综述和荟萃分析旨在探讨埃塞俄比亚与抗逆转录病毒疗法相关的药物不良反应的总体发生率。方法:本系统综述和荟萃分析针对在埃塞俄比亚生活的 HIV 患者进行的队列研究。研究报告采用了系统综述和荟萃分析首选报告项目(PRISMA)。随机效应荟萃分析用于确定ADR的总发生率。对异质性进行了评估,并使用亚组和敏感性分析对变异来源进行了分析。漏斗图和 Egger 回归检验用于研究发表偏倚。研究结果根据随机效应模型,从 10 项研究中提取的抗逆转录病毒疗法药物不良反应总发生率为每 100 人年 5.09(95% CI:3.86-6.71),具有显著的异质性(I 2 = 96.4%,P < 0.0001)。在多中心研究地区、采用前瞻性和回顾性设计的研究中,以及在儿童中观察到的亚组数据也更高。讨论:本系统综述和荟萃分析的结果显示了 ADR 发生率的差异。此外,本综述的结果还显示,在医疗保健系统中,艾滋病病毒感染者发生与抗逆转录病毒疗法相关的 ADR 的情况很普遍。结论本系统综述和荟萃分析强调了埃塞俄比亚抗逆转录病毒疗法诊所中被诊断为艾滋病病毒感染者的不良反应发生率很高。要解决这一问题并将药物警戒纳入服务提供中,卫生规划者、政策制定者和社区之间的全面战略和协调合作至关重要。
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来源期刊
AIDS Research and Treatment
AIDS Research and Treatment INFECTIOUS DISEASES-
CiteScore
3.10
自引率
0.00%
发文量
13
审稿时长
18 weeks
期刊介绍: AIDS Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focused on all aspects of HIV and AIDS, from the molecular basis of disease to translational and clinical research. In addition, articles relating to prevention, education, and behavior change will be considered
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