Mindy Goldman, David McKee, Shane Smith, Sheila F O'Brien
{"title":"Removal of deferrals for variant Creutzfeldt-Jakob disease risk: Impact on new and previously deferred donors.","authors":"Mindy Goldman, David McKee, Shane Smith, Sheila F O'Brien","doi":"10.1111/vox.70021","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>Concern over variant Creutzfeldt-Jakob disease (vCJD) led to the deferral of donors who had resided in the United Kingdom since January 1980. This deferral was implemented in 1999 and subsequently modified to include other countries. Some deferrals were removed in February 2022; deferrals for the United Kingdom, Ireland and France were removed on 22 November 2023. In this study, we describe efforts made to encourage donation from newly eligible people and the resulting donation gain.</p><p><strong>Materials and methods: </strong>Actions targeted individual donors deferred after 1 January 2012. Marketing included website, social media and general advertising. Staff asked first-time donors if the criteria change had motivated their donation. Deferred and returning donor data were determined from our donor database.</p><p><strong>Results: </strong>In the 12 months post-implementation, 12.8% of first-time donors surveyed were newly eligible (n = 8667) and 7.8% of vCJD risk deferred donors returned (n = 5159). Eighty-five percent of deferrals occurred pre-2017; the return rate was 6.5% in this group. The highest return rate (24%) occurred in donors deferred after 2020.</p><p><strong>Conclusion: </strong>Removal of the vCJD deferrals had a major positive impact. The greatest gain was in new donors who had previously self-deferred. Despite intensive efforts, only one-quarter of recently deferred donors returned.</p>","PeriodicalId":23631,"journal":{"name":"Vox Sanguinis","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vox Sanguinis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/vox.70021","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objectives: Concern over variant Creutzfeldt-Jakob disease (vCJD) led to the deferral of donors who had resided in the United Kingdom since January 1980. This deferral was implemented in 1999 and subsequently modified to include other countries. Some deferrals were removed in February 2022; deferrals for the United Kingdom, Ireland and France were removed on 22 November 2023. In this study, we describe efforts made to encourage donation from newly eligible people and the resulting donation gain.
Materials and methods: Actions targeted individual donors deferred after 1 January 2012. Marketing included website, social media and general advertising. Staff asked first-time donors if the criteria change had motivated their donation. Deferred and returning donor data were determined from our donor database.
Results: In the 12 months post-implementation, 12.8% of first-time donors surveyed were newly eligible (n = 8667) and 7.8% of vCJD risk deferred donors returned (n = 5159). Eighty-five percent of deferrals occurred pre-2017; the return rate was 6.5% in this group. The highest return rate (24%) occurred in donors deferred after 2020.
Conclusion: Removal of the vCJD deferrals had a major positive impact. The greatest gain was in new donors who had previously self-deferred. Despite intensive efforts, only one-quarter of recently deferred donors returned.
期刊介绍:
Vox Sanguinis reports on important, novel developments in transfusion medicine. Original papers, reviews and international fora are published on all aspects of blood transfusion and tissue transplantation, comprising five main sections:
1) Transfusion - Transmitted Disease and its Prevention:
Identification and epidemiology of infectious agents transmissible by blood;
Bacterial contamination of blood components;
Donor recruitment and selection methods;
Pathogen inactivation.
2) Blood Component Collection and Production:
Blood collection methods and devices (including apheresis);
Plasma fractionation techniques and plasma derivatives;
Preparation of labile blood components;
Inventory management;
Hematopoietic progenitor cell collection and storage;
Collection and storage of tissues;
Quality management and good manufacturing practice;
Automation and information technology.
3) Transfusion Medicine and New Therapies:
Transfusion thresholds and audits;
Haemovigilance;
Clinical trials regarding appropriate haemotherapy;
Non-infectious adverse affects of transfusion;
Therapeutic apheresis;
Support of transplant patients;
Gene therapy and immunotherapy.
4) Immunohaematology and Immunogenetics:
Autoimmunity in haematology;
Alloimmunity of blood;
Pre-transfusion testing;
Immunodiagnostics;
Immunobiology;
Complement in immunohaematology;
Blood typing reagents;
Genetic markers of blood cells and serum proteins: polymorphisms and function;
Genetic markers and disease;
Parentage testing and forensic immunohaematology.
5) Cellular Therapy:
Cell-based therapies;
Stem cell sources;
Stem cell processing and storage;
Stem cell products;
Stem cell plasticity;
Regenerative medicine with cells;
Cellular immunotherapy;
Molecular therapy;
Gene therapy.