Assessing iron depletion in regular platelet apheresis donors: A comparison of reticulocyte haemoglobin and serum ferritin.

IF 1.8 4区 医学 Q3 HEMATOLOGY
Vox Sanguinis Pub Date : 2025-03-24 DOI:10.1111/vox.70023
Parintorn Nakdee, Thanatphak Warindpong, Sutasinee Virat, Parichart Permpikul, Janejira Kittivorapart
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Abstract

Background and objectives: Frequent platelet apheresis donations can lead to iron depletion. Serum ferritin is traditionally measured to assess iron status in donors. Reticulocyte haemoglobin (RET-He) has emerged as a rapid, convenient and cost-effective alternative. This study aimed to determine the prevalence of iron depletion among regular platelet apheresis donors and to evaluate the sensitivity and specificity of RET-He compared to serum ferritin in diagnosing iron depletion.

Materials and methods: This cross-sectional study involved 100 healthy, regular platelet apheresis donors aged 18-60 years who donated at least once a month. RET-He, serum ferritin and complete blood count results were analysed. The sensitivity and specificity of RET-He were calculated against serum ferritin.

Results: Of the 100 donors, 13.00% (13 out of 100 donors) had serum ferritin levels <15 ng/mL, indicating iron depletion. RET-He showed a sensitivity of 76.92% (95% confidence interval [95% CI]: 46.19%-94.96%) and specificity of 44.83% (95% CI: 34.15%-55.87%) in detecting iron depletion. Significant differences in RET-He levels, donation frequency, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, white blood cell count and red cell distribution width were detected between the iron-depleted and non-iron-depleted groups (p = 0.045, 0.032, 0.053, 0.026, 0.069 and 0.027, respectively).

Conclusion: Frequent platelet donations increase the risk of iron depletion; therefore, iron supplementation is recommended for regular donors. While RET-He testing is convenient, cost effective and fast, it cannot replace serum ferritin testing because of insufficient sensitivity and specificity.

评估常规血小板分离供者的铁消耗:网织红细胞血红蛋白和血清铁蛋白的比较。
背景和目的:频繁的血小板分离捐献可导致铁的耗竭。血清铁蛋白传统上是用来评估供体铁的状态。网织红细胞血红蛋白(RET-He)已成为一种快速、方便和具有成本效益的替代方法。本研究旨在确定常规血小板单采供者中铁缺失的发生率,并评估RET-He与血清铁蛋白在诊断铁缺失方面的敏感性和特异性。材料和方法:这项横断面研究涉及100名年龄在18-60岁、每月至少捐献一次的健康、定期的血小板分离献血者。分析RET-He、血清铁蛋白及全血细胞计数结果。计算RET-He对血清铁蛋白的敏感性和特异性。结果:100例献血者中有13.00%(13例)血清铁蛋白水平正常。结论:频繁血小板捐献增加了铁衰竭的风险;因此,建议定期供体补充铁。虽然RET-He检测方便、经济、快速,但由于灵敏度和特异性不足,不能代替血清铁蛋白检测。
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来源期刊
Vox Sanguinis
Vox Sanguinis 医学-血液学
CiteScore
4.40
自引率
11.10%
发文量
156
审稿时长
6-12 weeks
期刊介绍: Vox Sanguinis reports on important, novel developments in transfusion medicine. Original papers, reviews and international fora are published on all aspects of blood transfusion and tissue transplantation, comprising five main sections: 1) Transfusion - Transmitted Disease and its Prevention: Identification and epidemiology of infectious agents transmissible by blood; Bacterial contamination of blood components; Donor recruitment and selection methods; Pathogen inactivation. 2) Blood Component Collection and Production: Blood collection methods and devices (including apheresis); Plasma fractionation techniques and plasma derivatives; Preparation of labile blood components; Inventory management; Hematopoietic progenitor cell collection and storage; Collection and storage of tissues; Quality management and good manufacturing practice; Automation and information technology. 3) Transfusion Medicine and New Therapies: Transfusion thresholds and audits; Haemovigilance; Clinical trials regarding appropriate haemotherapy; Non-infectious adverse affects of transfusion; Therapeutic apheresis; Support of transplant patients; Gene therapy and immunotherapy. 4) Immunohaematology and Immunogenetics: Autoimmunity in haematology; Alloimmunity of blood; Pre-transfusion testing; Immunodiagnostics; Immunobiology; Complement in immunohaematology; Blood typing reagents; Genetic markers of blood cells and serum proteins: polymorphisms and function; Genetic markers and disease; Parentage testing and forensic immunohaematology. 5) Cellular Therapy: Cell-based therapies; Stem cell sources; Stem cell processing and storage; Stem cell products; Stem cell plasticity; Regenerative medicine with cells; Cellular immunotherapy; Molecular therapy; Gene therapy.
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