Effects of Two Different Basic Skincare Regimens on Children and Adult Skin Microbiota: An Exploratory Randomized Controlled Crossover Trial.

IF 2.8 4区医学 Q2 DERMATOLOGY

Skin Pharmacology and Physiology Pub Date : 2025-03-24 DOI:10.1159/000545433

Kathrin Hillmann, Tsenka Tomova-Simitchieva, Pauline Sophia Pinta, Zhile Xiong, Annette Moter, Varvara Kanti-Schmidt, Jan Kottner, Ulrike Blume-Peytavi

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引用次数: 0

Abstract

Introduction: Regular use of leave-on skincare products has positive effects on the skin barrier and appears to influence the skin microbiome in atopic dermatitis (AD). However, product-related effects on the skin microbiome are unclear. The aim of this study was to investigate to which extent the application of an emollient plus product differs from a petrolatum-based basic skincare product in terms of skin physiology, skin barrier, and skin microbiome.

Methods: In an exploratory study regime, 50 subjects (children and adults) with mild AD were randomized to receive Bepanthen SensiDaily® (BSD) and Basiscreme DAC (DAC) for 3 months in a crossover design. Skin physiological measurements and skin microbiome swabs were taken on the forearm and lower leg before and after each 3-month application period of the respective product.

Results: Improvement of skin physiological parameters after 3 months was observed in both topical leave-on product groups. Statistically significant differences were observed in baseline microbiomes between children and adults (p < 0.001) but not between the product groups.

Conclusion: Regular application of leave-on products leads to better stratum corneum hydration after 3 months with better effects of BSD on the forearms of children and the lower legs of adults compared to DAC. The application of BSD and DAC did not lead to significant alterations in the overall composition of the skin microbiome. Although there were shifts in the frequency of certain microbial genera, these changes were not consistent between age groups and treatments.

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两种不同基础护肤方案对儿童和成人皮肤微生物群的影响：一项探索性随机对照交叉试验。

经常使用免洗护肤产品对皮肤屏障有积极作用，似乎会影响特应性皮炎（AD）的皮肤微生物群。然而，产品对皮肤微生物群的相关影响尚不清楚。本研究的目的是调查润肤产品的应用在多大程度上不同于凡士林基础护肤产品在皮肤生理，皮肤屏障和皮肤微生物组方面。在一项探索性研究方案中，50名轻度AD患者（儿童和成人）在交叉设计中随机接受Bepanthen SensiDaily®（BSD）和Basiscreme DAC (DAC)，为期3个月。在每个3个月的产品使用前后，分别对前臂和小腿进行皮肤生理测量和皮肤微生物组拭子采集。3个月后，两组皮肤生理参数均有改善。在儿童和成人的基线微生物组中观察到具有统计学意义的差异(p

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来源期刊

Skin Pharmacology and Physiology 医学-皮肤病学

CiteScore

5.20

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.