Like pashtun like haplogroup.

IF 1.1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jabbar Khan, Zia Ur Rehman, Zafar Uddin, Zahid Rauf, Li Yuchun, Muzammil Ahmad Khan, Muhammad Muzammal
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引用次数: 0

Abstract

The hypervariable HVS-I and HVS-II regions of mitochondrial genome of 124 longevity individuals (age 90 years) and 46 non-longevity individuals (age 65 years) of purely Pashtun ethnicity were characterized for forensic purposes. Blood samples were collected from southern belt of Khyber Pakhtunkhwa (KP) province. For exploring the genetic architect of mitochondrial DNA of Pashtun longevity individuals. Sequence analysis revealed 16 major haplogroups and 56 sub-haplogroups in longevity persons and, 12 and 29 major and sub-haplogroups in non-longevity persons respectively. The 3 most common major haplogroups in longevity individuals were [M (25.0%), J (14.51%), D and U (13 = 10.48% each)], while in non-longevity human, these were [M (17.39%), H & T (15.21% each), and D (13.04%)]. Nineteen unique point mutations were identified not reported previously in reference sequence. More interestingly, the position of mutations found in non-longevity individuals were not observed in longevity individuals and vice versa. Data presented here may contribute to the accuracy of forensic mtDNA comparisons in the Pashtun of Pakistan. Social, cultural and unique territorial factors contribute to heterogeneous nature of Pashtun ethnic group.

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来源期刊
Nucleosides, Nucleotides & Nucleic Acids
Nucleosides, Nucleotides & Nucleic Acids 生物-生化与分子生物学
CiteScore
2.60
自引率
7.70%
发文量
91
审稿时长
6 months
期刊介绍: Nucleosides, Nucleotides & Nucleic Acids publishes research articles, short notices, and concise, critical reviews of related topics that focus on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. Complete with experimental details, this all-inclusive journal emphasizes the synthesis, biological activities, new and improved synthetic methods, and significant observations related to new compounds.
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