Rest-Activity Disturbances Correlate with Core Features in Dementia with Lewy Bodies.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-03-25 DOI:10.1002/mdc3.70052

Jack Anderson, Nicholas K H Chiu, Jonathon E Pye, Maria Comas-Soberats, Aaron Lam, Ronald R Grunstein, Simon J G Lewis, Elie Matar

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引用次数: 0

Abstract

Background: Sleep-wake disturbances are a clinically important and poorly studied feature of dementia with Lewy bodies (DLB) due to the challenges of in-laboratory polysomnography in this population.

Objectives: To compare rest-activity rhythms in DLB, Parkinson's disease (PD), and age-matched controls using home-based wrist actigraphy and examine their relationship with core clinical DLB features.

Methods: Eleven DLB patients, 12 PD patients, and 11 age-matched controls underwent clinical assessment. Actigraphy data were obtained over 14 days and analyzed using nonparametric methods.

Results: DLB patients demonstrated higher rest-activity rhythm fragmentation (P = 0.002) than controls and lower circadian amplitude (P = 0.011) than both PD and controls. Instability of rest-activity rhythm was positively correlated with hallucinations (P = 0.009) and cognitive fluctuations (P = 0.016) in DLB, and reduced daytime activity correlated with severity of motor parkinsonism (P = 0.013). No such correlations were observed in PD.

Conclusions: Actigraphy detects distinct rest-activity rhythm disruptions in DLB, differentiating it from PD and controls. These measures are associated with the severity of core clinical features in DLB.

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休息-活动障碍与路易体痴呆症的核心特征相关。

背景：睡眠-觉醒障碍是路易体痴呆症（DLB）的一个重要临床特征，但对其研究较少，原因是在该人群中进行实验室多导睡眠监测存在困难：使用家庭腕部活动记录仪比较 DLB、帕金森病（PD）和年龄匹配对照组的休息-活动节律，并研究它们与 DLB 核心临床特征的关系：11名DLB患者、12名帕金森病患者和11名年龄匹配的对照组患者接受了临床评估。结果：DLB 患者的静息动图较高，而 PD 患者的静息动图较低：结果：与对照组相比，DLB 患者表现出更高的静息活动节律片段化（P = 0.002），与 PD 和对照组相比，DLB 患者的昼夜节律振幅更低（P = 0.011）。静息-活动节律的不稳定性与 DLB 患者的幻觉（P = 0.009）和认知波动（P = 0.016）呈正相关，日间活动减少与运动性帕金森病的严重程度相关（P = 0.013）。在帕金森病中未观察到此类相关性：结论：在 DLB 患者中，动觉描记术可检测到明显的静息-活动节律紊乱，从而将其与帕金森病和对照组区分开来。这些测量结果与 DLB 核心临床特征的严重程度相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)