Progenitor cells and circulating endothelial cells are associated with disease activity and damage in systemic lupus erythematosus patients.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI:10.1177/09612033251330124
Gonzalo Silveira, Sabrina Ranero, Adriana Carlomagno, Andreina Brugnini, Natalia Trias, Daniela Lens, Martín Rebella, Álvaro Danza, Sofía Grille
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Abstract

BackgroundDespite advancements in treatment, patients with Systemic Lupus Erythematosus (SLE) frequently experience disease flares, which contribute to organ damage and increase the risk of premature death. Assessing disease activity is essential for optimizing treatment and preventing further organ damage. This study aimed to investigate the relationship between levels of progenitor and circulating endothelial cells and SLE disease activity, as well as accumulated organ damage.MethodsWe conducted a case-control study measuring levels of CD34+CD45low/- progenitor cells, CD34+CD45low/-CD133+ progenitor cells, Endothelial Progenitor Cells (EPC), and Circulating Endothelial Cells (CEC) in peripheral blood using flow cytometry.ResultsThe study included 32 SLE patients and 28 matched controls. SLE patients exhibited significantly lower levels of CD34+CD45low/- progenitor cells (p = .001), CD34+CD45low/-CD133+ progenitor cells (p = .016), EPC (p = .018), and CEC (p < .001) compared to controls. Additionally, the cell subpopulations correlated with SLE activity biomarkers, with CD34+CD45low/- progenitor cells showing a moderate negative correlation with C3 and C4 levels. Notably, patients with an SDI score ≥1 had significantly higher levels of CD34+CD45low/- progenitor cells, CD34+CD45low/- CD133+ progenitor cells, EPC, and CEC compared to those without organ damage (p = .0073, p = .018, p = .018, and p = .020, respectively).ConclusionOur findings reveal that CD34+CD45low/- progenitor cells, CD34+CD45low/-CD133+ progenitor cells, EPC, and CEC are significantly reduced in SLE patients and are associated with disease activity and organ damage. These results suggest that CD34+CD45low/- progenitor cells, in particular, could serve as potential biomarkers for monitoring disease activity and organ damage in SLE patients. Prospective studies are warranted to confirm these findings.

祖细胞和循环内皮细胞与系统性红斑狼疮患者的疾病活动性和损伤有关。
背景:尽管治疗取得了进步,系统性红斑狼疮(SLE)患者经常经历疾病发作,这有助于器官损伤并增加过早死亡的风险。评估疾病活动对于优化治疗和防止进一步的器官损害至关重要。本研究旨在探讨祖细胞和循环内皮细胞水平与SLE疾病活动性以及累积器官损伤之间的关系。方法采用流式细胞术检测外周血中CD34+ cd45低/-祖细胞、CD34+ cd45低/- cd133 +祖细胞、内皮祖细胞(EPC)和循环内皮细胞(CEC)水平。结果本研究纳入32例SLE患者和28例对照组。与对照组相比,SLE患者CD34+CD45low/-祖细胞(p = 0.001)、CD34+CD45low/- cd133 +祖细胞(p = 0.016)、EPC (p = 0.018)和CEC (p < 0.001)水平显著降低。此外,细胞亚群与SLE活性生物标志物相关,CD34+CD45low/-祖细胞与C3和C4水平呈中度负相关。值得注意的是,SDI评分≥1的患者CD34+CD45low/-祖细胞、CD34+CD45low/- CD133+祖细胞、EPC和CEC水平明显高于无器官损害的患者(p = 0.0073、p = 0.018、p = 0.018和p = 0.020)。结论CD34+CD45low/-祖细胞、CD34+CD45low/- cd133 +祖细胞、EPC和CEC在SLE患者中显著降低,且与疾病活动性和器官损害相关。这些结果表明,特别是CD34+CD45low/-祖细胞,可以作为监测SLE患者疾病活动性和器官损伤的潜在生物标志物。有必要进行前瞻性研究来证实这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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