Comparation of tumor-free margin or intralesional spondylectomy for chondrosarcoma in mobile spine: a retrospective study of surgery management, complications and prognosis.

IF 2.8 3区 医学 Q1 ORTHOPEDICS
Fangzhi Liu, Ben Wang, Xiaoguang Liu, Fengliang Wu, Hua Zhou, Lei Dang, Yan Li, Yanchao Tang, Xiao Liu, Panpan Hu, Zihe Li, Feng Wei, Zhongjun Liu
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引用次数: 0

Abstract

Study design: Retrospective Cohort Study.

Objectives: Chondrosarcoma of mobile spine is a rare aggressive malignant tumor and postsurgical local recurrence rates remain high. En bloc resection is currently the preferred treatment. Resection that achieves tumor-free margin removal of the tumor may enable more complete removal of tumor tissue but significantly increases the complexity and risk of surgery and results in more postoperative complications. We sought to compare surgical outcomes, complications, and prognoses between patients who underwent en bloc resection with and without intralesional removal of the tumor.

Methods: We reviewed 56 patients with spinal chondrosarcoma who underwent en bloc tumor resection and reconstructive surgery at our center between 2000 and 2024 with a minimum postoperative follow-up of 1 year. We collected and analyzed data regarding surgical procedures, complication characteristics, and local tumor control and recurrence.

Results: We included 56 patients. Of these, 36 patients underwent the first surgery, and 20 experienced recurrences. All patients underwent en bloc tumor resection; 36 and 20 underwent intralesional and tumor-free margin resections, respectively. We recorded 83 complications; the incidence and the number of major complications were significantly higher in the tumor-free margin surgery group. Thirty patients experienced tumor recurrence and 26 patients died. Tumor-free margin en bloc resection and conventional-type chondrosarcoma were predictive factors for reduced long-term postoperative recurrence and mortality risk.

Conclusions: Tumor-free margin resection carries higher risks and is associated with a greater number of perioperative complications, but reduces the risk of local tumor recurrence and prolongs recurrence-free survival and overall survival, providing patients with better prognoses.

活动脊柱软骨肉瘤行无瘤缘或椎体内切除的比较:手术处理、并发症和预后的回顾性研究。
研究设计:回顾性队列研究。目的:活动脊柱软骨肉瘤是一种罕见的侵袭性恶性肿瘤,术后局部复发率很高。整体切除是目前首选的治疗方法。切除达到无肿瘤边缘切除的肿瘤可以更完整地切除肿瘤组织,但明显增加了手术的复杂性和风险,并导致更多的术后并发症。我们试图比较手术结果,并发症和患者之间的预后进行整体切除和不切除病灶内的肿瘤。方法:我们回顾了2000年至2024年间在我中心接受整体肿瘤切除和重建手术的56例脊柱软骨肉瘤患者,术后随访时间至少为1年。我们收集并分析了有关手术方法、并发症特征、局部肿瘤控制和复发的资料。结果:我们纳入56例患者。其中,36例患者接受了第一次手术,20例复发。所有患者均行肿瘤整体切除;36例和20例分别行瘤内和无瘤边缘切除术。我们记录了83例并发症;无肿瘤切缘手术组主要并发症的发生率和数量明显高于无肿瘤切缘手术组。肿瘤复发30例,死亡26例。无瘤边缘整体切除和常规型软骨肉瘤是降低术后长期复发和死亡风险的预测因素。结论:无瘤切缘切除术风险较高,围手术期并发症较多,但可降低肿瘤局部复发风险,延长无复发生存期和总生存期,为患者提供更好的预后。
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来源期刊
CiteScore
4.10
自引率
7.70%
发文量
494
审稿时长
>12 weeks
期刊介绍: Journal of Orthopaedic Surgery and Research is an open access journal that encompasses all aspects of clinical and basic research studies related to musculoskeletal issues. Orthopaedic research is conducted at clinical and basic science levels. With the advancement of new technologies and the increasing expectation and demand from doctors and patients, we are witnessing an enormous growth in clinical orthopaedic research, particularly in the fields of traumatology, spinal surgery, joint replacement, sports medicine, musculoskeletal tumour management, hand microsurgery, foot and ankle surgery, paediatric orthopaedic, and orthopaedic rehabilitation. The involvement of basic science ranges from molecular, cellular, structural and functional perspectives to tissue engineering, gait analysis, automation and robotic surgery. Implant and biomaterial designs are new disciplines that complement clinical applications. JOSR encourages the publication of multidisciplinary research with collaboration amongst clinicians and scientists from different disciplines, which will be the trend in the coming decades.
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