Hematology thin smears perform equally to parasitology thick and thin blood smears for the diagnosis of Plasmodium and Babesia infections in a low prevalence setting.

IF 6.1 2区 医学 Q1 MICROBIOLOGY
Janmesh Patel, Jill Schuett, Derrick J Chen
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引用次数: 0

Abstract

Malaria and babesiosis are significant parasitic infections, requiring timely diagnosis to avoid severe complications. This study retrospectively compared hematology thin smears (HS) with parasitology thick and thin blood smears (PS), the gold standard for diagnosis, to evaluate HS's performance in detecting Plasmodium and Babesia infections. Of 529 cases with paired HS and PS testing, HS demonstrated 93.3% sensitivity and 99.8% specificity, with 97.7% positive and 99.4% negative predictive values. When only considering new diagnoses, HS and PS were 100% concordant. No significant difference was found in percent parasitemia between HS and PS, highlighting HS as a reliable diagnostic tool in settings where PS or other diagnostic modalities may not be readily available.IMPORTANCEThis study demonstrates that hematology thin smears-often available in laboratories that may not have other means of diagnosing blood parasite infections such as parasitology thick and thin smears, rapid diagnostics tests, or polymerase chain reaction-are an accurate and reliable way to diagnose Plasmodium and Babesia infections in a low prevalence setting.

在低流行率环境中,血液学薄血涂片与寄生虫学厚血涂片和薄血涂片在诊断疟原虫和巴贝虫感染方面的作用相同。
疟疾和巴贝斯虫病是严重的寄生虫感染,需要及时诊断以避免严重并发症。本研究回顾性比较血液学薄涂片(HS)与寄生虫学厚、薄血涂片(PS)作为诊断金标准,评价HS检测疟原虫和巴贝虫感染的效果。在529例HS和PS配对检测的病例中,HS的敏感性为93.3%,特异性为99.8%,阳性预测值为97.7%,阴性预测值为99.4%。仅考虑新诊断时,HS和PS的一致性为100%。HS和PS在寄生虫率方面没有发现显著差异,这突出表明HS在PS或其他诊断方式可能不容易获得的情况下是一种可靠的诊断工具。重要意义本研究表明,血液学薄涂片(通常在实验室中可用,可能没有其他诊断血液寄生虫感染的手段,如寄生虫学厚涂片和薄涂片,快速诊断测试或聚合酶链反应)是在低流行环境中诊断疟原虫和巴贝虫感染的准确可靠的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Microbiology
Journal of Clinical Microbiology 医学-微生物学
CiteScore
17.10
自引率
4.30%
发文量
347
审稿时长
3 months
期刊介绍: The Journal of Clinical Microbiology® disseminates the latest research concerning the laboratory diagnosis of human and animal infections, along with the laboratory's role in epidemiology and the management of infectious diseases.
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