Pyrimidine-Based Compounds in Tuberculosis Management: A Review of their Biological and Medicinal Importance.

Abstract

Pyrimidine derivatives are a class of chemically & biologically active heterocyclic compounds promising for developing anti-tubercular, anti-viral, anti-malarial, anti-inflammatory, and enzyme-inhibiting drugs. To cure TB, scientists were driven to establish novel pyrimidine derivatives. The main objective of the current review is to identify and develop new pyrimidine moietycontaining derivatives that have been assessed for their structure-activity relationship (SAR). The emergence and widespread spread of several drug-resistant MTB infections, which renders firstline anti-TB medications more ineffective. It is crucial to develop new anti-TB drugs that are extremely effective against both drug-sensitive and drug-resistant TB. The development of pyrimidine therapeutics methods will thus benefit from the current review. Three medications-GSK-286, TBA- 7371, and SPR-720 are now undergoing clinical testing. This study aims to emphasize the structural variety of anti-tuberculosis pyrimidine-containing compounds by providing an overview of current developments in drug discovery investigations.